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    Results: 1 to 20 of 110

    1.

    Does contractile Ca2+ control calcineurin-NFAT signaling and pathological hypertrophy in cardiac myocytes?

    Houser SR, Molkentin JD.

    Sci Signal. 2008 Jun 24;1(25):pe31. doi: 10.1126/scisignal.125pe31.

    PMID:
    18577756
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    2.

    Cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice.

    Oliveira RS, Ferreira JC, Gomes ER, Paixão NA, Rolim NP, Medeiros A, Guatimosim S, Brum PC.

    J Physiol. 2009 Aug 1;587(Pt 15):3899-910. doi: 10.1113/jphysiol.2009.173948. Epub 2009 Jun 8.

    PMID:
    19505981
    [PubMed - indexed for MEDLINE]
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    3.

    CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes.

    MacDonnell SM, Weisser-Thomas J, Kubo H, Hanscome M, Liu Q, Jaleel N, Berretta R, Chen X, Brown JH, Sabri AK, Molkentin JD, Houser SR.

    Circ Res. 2009 Aug 14;105(4):316-25. doi: 10.1161/CIRCRESAHA.109.194035. Epub 2009 Jul 16.

    PMID:
    19608982
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    4.

    Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts.

    Tang M, Li J, Huang W, Su H, Liang Q, Tian Z, Horak KM, Molkentin JD, Wang X.

    Cardiovasc Res. 2010 Dec 1;88(3):424-33. doi: 10.1093/cvr/cvq217. Epub 2010 Jul 2.

    PMID:
    20601385
    [PubMed - indexed for MEDLINE]
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    5.

    Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy.

    Wilkins BJ, Dai YS, Bueno OF, Parsons SA, Xu J, Plank DM, Jones F, Kimball TR, Molkentin JD.

    Circ Res. 2004 Jan 9;94(1):110-8. Epub 2003 Dec 1.

    PMID:
    14656927
    [PubMed - indexed for MEDLINE]
    Free Article

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    6.

    Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure.

    Nakamura TY, Iwata Y, Arai Y, Komamura K, Wakabayashi S.

    Circ Res. 2008 Oct 10;103(8):891-9. doi: 10.1161/CIRCRESAHA.108.175141. Epub 2008 Sep 5.

    PMID:
    18776042
    [PubMed - indexed for MEDLINE]
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    7.

    Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes.

    Fiedler B, Lohmann SM, Smolenski A, Linnemuller S, Pieske B, Schroder F, Molkentin JD, Drexler H, Wollert KC.

    Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11363-8. Epub 2002 Aug 12.

    PMID:
    12177418
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    8.

    TRPC channels as effectors of cardiac hypertrophy.

    Eder P, Molkentin JD.

    Circ Res. 2011 Jan 21;108(2):265-72. doi: 10.1161/CIRCRESAHA.110.225888. Review.

    PMID:
    21252153
    [PubMed - indexed for MEDLINE]
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    9.

    Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure.

    Rinne A, Kapur N, Molkentin JD, Pogwizd SM, Bers DM, Banach K, Blatter LA.

    Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H2001-9. doi: 10.1152/ajpheart.01072.2009. Epub 2010 Mar 19.

    PMID:
    20304816
    [PubMed - indexed for MEDLINE]
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    10.

    PICOT attenuates cardiac hypertrophy by disrupting calcineurin-NFAT signaling.

    Jeong D, Kim JM, Cha H, Oh JG, Park J, Yun SH, Ju ES, Jeon ES, Hajjar RJ, Park WJ.

    Circ Res. 2008 Mar 28;102(6):711-9. doi: 10.1161/CIRCRESAHA.107.165985. Epub 2008 Feb 7.

    PMID:
    18258855
    [PubMed - indexed for MEDLINE]
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    11.

    Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth.

    Sanna B, Bueno OF, Dai YS, Wilkins BJ, Molkentin JD.

    Mol Cell Biol. 2005 Feb;25(3):865-78.

    PMID:
    15657416
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    12.

    Ca2+ oscillation frequency decoding in cardiac cell hypertrophy: role of calcineurin/NFAT as Ca2+ signal integrators.

    Colella M, Grisan F, Robert V, Turner JD, Thomas AP, Pozzan T.

    Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2859-64. doi: 10.1073/pnas.0712316105. Epub 2008 Feb 19.

    PMID:
    18287024
    [PubMed - indexed for MEDLINE]
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    13.

    Calcium-calcineurin signaling in the regulation of cardiac hypertrophy.

    Wilkins BJ, Molkentin JD.

    Biochem Biophys Res Commun. 2004 Oct 1;322(4):1178-91. Review.

    PMID:
    15336966
    [PubMed - indexed for MEDLINE]

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    14.

    Ca(2+) influx through L-type Ca(2+) channels and transient receptor potential channels activates pathological hypertrophy signaling.

    Gao H, Wang F, Wang W, Makarewich CA, Zhang H, Kubo H, Berretta RM, Barr LA, Molkentin JD, Houser SR.

    J Mol Cell Cardiol. 2012 Nov;53(5):657-67. doi: 10.1016/j.yjmcc.2012.08.005. Epub 2012 Aug 21.

    PMID:
    22921230
    [PubMed - indexed for MEDLINE]

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    15.

    Interference of antihypertrophic molecules and signaling pathways with the Ca2+-calcineurin-NFAT cascade in cardiac myocytes.

    Fiedler B, Wollert KC.

    Cardiovasc Res. 2004 Aug 15;63(3):450-7. Review.

    PMID:
    15276470
    [PubMed - indexed for MEDLINE]
    Free Article

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    16.

    Requirement of nuclear factor of activated T-cells in calcineurin-mediated cardiomyocyte hypertrophy.

    van Rooij E, Doevendans PA, de Theije CC, Babiker FA, Molkentin JD, de Windt LJ.

    J Biol Chem. 2002 Dec 13;277(50):48617-26. Epub 2002 Sep 10.

    PMID:
    12226086
    [PubMed - indexed for MEDLINE]
    Free Article

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    17.

    O-GlcNAc signaling is essential for NFAT-mediated transcriptional reprogramming during cardiomyocyte hypertrophy.

    Facundo HT, Brainard RE, Watson LJ, Ngoh GA, Hamid T, Prabhu SD, Jones SP.

    Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H2122-30. doi: 10.1152/ajpheart.00775.2011. Epub 2012 Mar 9.

    PMID:
    22408028
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    18.

    Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.

    Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K, Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR.

    J Mol Cell Cardiol. 2011 Mar;50(3):460-70. doi: 10.1016/j.yjmcc.2010.11.012. Epub 2010 Nov 25.

    PMID:
    21111744
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    19.

    Effects of thapsigargin and phenylephrine on calcineurin and protein kinase C signaling functions in cardiac myocytes.

    Prasad AM, Inesi G.

    Am J Physiol Cell Physiol. 2009 May;296(5):C992-C1002. doi: 10.1152/ajpcell.00594.2008. Epub 2009 Feb 25.

    PMID:
    19244478
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    20.

    Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo.

    Grebe C, Klingebiel TM, Grau SP, Toischer K, Didié M, Jacobshagen C, Dullin C, Hasenfuss G, Seidler T.

    Cardiovasc Res. 2011 Jun 1;90(3):521-8. doi: 10.1093/cvr/cvr023. Epub 2011 Jan 27.

    PMID:
    21273244
    [PubMed - indexed for MEDLINE]
    Free Article

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