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The Genome Reference Consortium

Putting sequences into a chromosome context.

The original model for representing the genome assemblies was to use a single, preferred tiling path to produce a single consensus representation of the genome. Subsequent analysis has shown that for most mammalian genomes a single tiling path is insufficient to represent a genome in regions with complex allelic diversity. The GRC is now working to create assemblies that better represent this diversity and provide more robust substrates for genome analysis.

Slides from the GRC workshop at AGBT 2015 are available on Slideshare.

Check out the publication " Extending reference assembly models" to learn more about the current reference assembly model and how it impacts tools and data reporting.

Transitioning to GRCh38 or GRCz10? Try the NCBI Remapping Service, which uses the same assembly-assembly alignments used by the GRC.

Subscribe to the grc-announce email list to receive email notification for all GRC assembly updates.

Page last updated: January 2, 2014

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