1061 COGs

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 2  5  7 12 ------|------|  14    [P]     COG0748 Putative heme iron utilization protein
 2  4  6 12 ------|------|  21    [E]     COG0754 Glutathionylspermidine synthase
 2  6 10 19 ------|------|  21    [G]     COG0837 Glucokinase
 2  6 11 18 ------|------|  18    [C]     COG1049 Aconitase B
 2  5  5  5 |-----|-------   7    [R]     COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold
 2 10 10 12 |-|-----------  13    [L]     COG1111 ERCC4-like helicases
 2  7  7  8 |----|--------  16    [C]     COG1149 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain
 2  9  9 11 |-----------|-  11    [R]     COG1244 Predicted Fe-S oxidoreductase
 2  9 10 12 ||------------  12    [S]     COG1303 Uncharacterized protein conserved in archaea
 2  2  2  3 --------|-|---   3    [S]     COG1306 Uncharacterized conserved protein
 2  8 10 11 ||------------  12    [J]     COG1325 Predicted exosome subunit
 2  9 11 13 ||------------  13    [K    H]    COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon
 2  8 10 12 ||------------  13    [S]     COG1340 Uncharacterized archaeal coiled-coil protein
 2  3  6  9 ---------|---|   9    [C]     COG1347 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD
 2  9 11 13 ||------------  13    [O]     COG1370 Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit
 2  6  6  8 |-----------|-   9    [S]     COG1379 Uncharacterized conserved protein
 2  8 10 11 ||------------  11    [L]     COG1389 DNA topoisomerase VI, subunit B
 2  9 11 13 ||------------  13    [K]     COG1395 Predicted transcriptional regulator
 2  6  6  6 |----|--------   6    [L]     COG1421 Uncharacterized protein predicted to be involved in DNA repair
 2  4  4  4 |---|---------   4    [J]     COG1431 Uncharacterized protein containing piwi/argonaute domain
 2  4  7 13 ------------||  30    [M]     COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases
 2  9 11 13 ||------------  13    [S]     COG1460 DNA-directed RNA polymerase, subunit F
 2  7  7  7 |---|---------   7    [E]     COG1465 Predicted alternative 3-dehydroquinate synthase
 2  4  4  5 |-----------|-   6    [S]     COG1470 Predicted membrane protein
 2  9 11 13 ||------------  13    [J]     COG1491 Predicted RNA-binding protein
 2  6  8  8 ||------------   8    [S]     COG1531 Uncharacterized protein conserved in archaea
 2  9  9 11 ||------------  12    [J]     COG1549 Queuine tRNA-ribosyltransferases, contain PUA domain
 2  4  4  5 |---|---------   6    [R]     COG1568 Predicted methyltransferases
 2  9 11 13 ||------------  17    [R]     COG1571 Predicted DNA-binding protein containing a Zn-ribbon domain
 2  5  5  6 |-----|-------   9    [S]     COG1572 Uncharacterized conserved protein
 2  7  9 11 ||------------  15    [K]     COG1581 Archaeal DNA-binding protein
 2  9  9 11 ||------------  12    [J]     COG1588 RNase P/RNase MRP subunit p29
 2  7  9 10 ||------------  11    [L]     COG1591 Holliday junction resolvase - archaeal type
 2  8 10 12 ||------------  17    [S]     COG1602 Uncharacterized conserved protein
 2  9 11 13 ||------------  13    [R]     COG1608 Predicted archaeal kinase
 2  6  7  9 ||------------  10    [S]     COG1630 Uncharacterized protein conserved in archaea
 2  9 11 13 ||------------  13    [R]     COG1634 Uncharacterized Rossmann fold enzyme
 2  7  9 10 ||------------  10    [R]     COG1645 Uncharacterized Zn-finger containing protein
 2  8 10 12 ||------------  12    [S]     COG1650 Uncharacterized protein conserved in archaea
 2  6  6  6 ||------------   6    [S]     COG1665 Uncharacterized protein conserved in archaea
 2  5  6  7 ||------------  11    [S]     COG1673 Uncharacterized protein conserved in archaea
 2  7  8 10 ||------------  29    [N]     COG1681 Archaeal flagellins
 2  9 11 12 ||------------  12    [E    H]    COG1685 Archaeal shikimate kinase
 2  8  9 11 ||------------  11    [S]     COG1698 Uncharacterized protein conserved in archaea
 2  3  3  3 |---|---------   3    [S]     COG1700 Uncharacterized conserved protein
 2  8 10 11 ||------------  11    [S]     COG1701 Uncharacterized protein conserved in archaea
 2  8 10 12 ||------------  12    [K]     COG1709 Predicted transcriptional regulator
 2  3  6  9 ---------|---|   9    [C]     COG1726 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA
 2  4 10 19 ----|--------|  19    [S]     COG1729 Uncharacterized protein conserved in bacteria
 2  6  8  8 ||------------   8    [H]     COG1731 Archaeal riboflavin synthase
 2  9 11 13 ||------------  13    [J]     COG1746 tRNA nucleotidyltransferase (CCA-adding enzyme)
 2  2  2  4 ---------||---   4    [S]     COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA
 2  5  7  8 ||------------   9    [R]     COG1750 Archaeal serine proteases
 2  5  5  5 |----|--------   5    [S]     COG1751 Uncharacterized conserved protein
 2  7  8  9 ||------------  15    [R]     COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)
 2  9 11 13 ||------------  14    [R]     COG1782 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain
 2  6  6  6 |------------|   7    [S]     COG1795 Uncharacterized conserved protein
 2  5  5  6 ||------------   8    [S]     COG1817 Uncharacterized protein conserved in archaea
 2  7  7  8 ||------------  11    [P]     COG1824 Permease, similar to cation transporters
 2  8 10 11 ||------------  11    [R]     COG1829 Predicted archaeal kinase (sugar kinase superfamily)
 2  9 10 12 ||------------  12    [R]     COG1831 Predicted metal-dependent hydrolase (urease superfamily)
 2  9 11 13 ||------------  13    [S]     COG1849 Uncharacterized protein conserved in archaea
 2  3  3  4 |---|---------   4    [S]     COG1851 Uncharacterized conserved protein
 2  6  6  6 |-------|-----   7    [S]     COG1852 Uncharacterized conserved protein
 2  9 11 13 ||------------  13    [R]     COG1855 ATPase (PilT family)
 2  8  8  9 ||------------   9    [S]     COG1860 Uncharacterized protein conserved in archaea
 2 10 10 13 |-----------|-  25    [S]     COG1873 Uncharacterized conserved protein
 2  7  9 11 ||------------  11    [S]     COG1888 Uncharacterized protein conserved in archaea
 2  7  8  9 ||------------   9    [S]     COG1892 Uncharacterized protein conserved in archaea
 2  5  5  5 |----|--------   6    [S]     COG1895 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN
 2  7  7  7 |-----|-------  11    [S]     COG1900 Uncharacterized conserved protein
 2  7  8  9 ||------------  13    [R]     COG1907 Predicted archaeal sugar kinases
 2  8 10 12 ||------------  12    [S]     COG1909 Uncharacterized protein conserved in archaea
 2  6  6  6 |-----|-------   6    [S]     COG1915 Uncharacterized conserved protein
 2  7  7  9 |----------|--   9    [S]     COG1920 Uncharacterized conserved protein
 2  8 10 11 ||------------  11    [S]     COG1931 Uncharacterized protein conserved in archaea
 2  9 11 13 ||------------  17    [R]     COG1938 Archaeal enzymes of ATP-grasp superfamily
 2  8  8  9 |-----|-------  16    [C]     COG1941 Coenzyme F420-reducing hydrogenase, gamma subunit
 2  9  9 12 |--------|----  15    [S]     COG1945 Uncharacterized conserved protein
 2  4 11 22 |------------|  22    [U]     COG1952 Preprotein translocase subunit SecB
 2  7  8 10 ||------------  11    [N    U]    COG1955 Archaeal flagella assembly protein J
 2  3  3  8 ----|--------|   9    [C]     COG1969 Ni,Fe-hydrogenase I cytochrome b subunit
 2  6  6  6 ||------------   6    [O]     COG1973 Hydrogenase maturation factor
 2  6 10 17 ------|------|  17    [S]     COG1981 Predicted membrane protein
 2  4  4  4 |----|--------   4    [R]     COG2000 Predicted Fe-S protein
 2  8  9 11 ||------------  12    [S]     COG2034 Predicted membrane protein
 2  6  6  8 |------|------  10    [G]     COG2074 2-phosphoglycerate kinase
 2  7  9 10 ||------------  10    [S]     COG2090 Uncharacterized protein conserved in archaea
 2  9 11 13 ||------------  13    [K]     COG2093 DNA-directed RNA polymerase, subunit E''
 2  5  6  7 ||------------   7    [R]     COG2100 Predicted Fe-S oxidoreductase
 2  6  6  6 |------------|   6    [S]     COG2122 Uncharacterized conserved protein
 2  3  3 10 -----------|-|  10    [I]     COG2134 CDP-diacylglycerol pyrophosphatase
 2  5  5  5 |-----|-------   8    [R]     COG2144 Selenophosphate synthetase-related proteins
 2  6  6  6 |-----------|-   6    [R]     COG2158 Uncharacterized protein containing a Zn-finger-like domain
 2  3  3  3 |----|--------   3    [S]     COG2164 Uncharacterized conserved protein
 2  6  6  8 |------|------  12    [C]     COG2191 Formylmethanofuran dehydrogenase subunit E
 2  3  6  9 ---------|---|  10    [C]     COG2209 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE
 2  4  7 16 ------------||  20    [G]     COG2213 Phosphotransferase system, mannitol-specific IIBC component
 2  7  9 11 ||------------  12    [S]     COG2237 Predicted membrane protein
 2  3  3  4 |-----------|-   9    [M]     COG2247 Putative cell wall-binding domain
 2  5  7  8 ||------------   8    [R]     COG2248 Predicted hydrolase (metallo-beta-lactamase superfamily)
 2  3  3  5 |----------|--   9    [S]     COG2253 Uncharacterized conserved protein
 2  4  6  7 ||------------  11    [L]     COG2254 Predicted HD superfamily hydrolase, possibly a nuclease
 2  9 11 13 ||------------  13    [H]     COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase
 2  4  6  6 ||------------   6    [S]     COG2410 Uncharacterized conserved protein
 2  4  5  6 ||------------  10    [S]     COG2411 Uncharacterized conserved protein
 2  7  8 10 ||------------  10    [S]     COG2412 Uncharacterized conserved protein
 2  4  5  6 ||------------   7    [R]     COG2413 Predicted nucleotidyltransferase
 2  4  6  7 ||------------   7    [S]     COG2419 Uncharacterized conserved protein
 2  4  6  6 ||------------   7    [S]     COG2429 Uncharacterized conserved protein
 2  4  5  6 ||------------   7    [S]     COG2430 Uncharacterized conserved protein
 2  7  9 10 ||------------  11    [S]     COG2433 Uncharacterized conserved protein
 2  3  4  5 ||------------   5    [C]     COG2441 Predicted butyrate kinase
 2  7  7  8 ||------------   8    [S]     COG2457 Uncharacterized conserved protein
 2  9 11 13 ||------------  13    [J]     COG2511 Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain)
 2  5  7  9 ||------------  18    [S]     COG2512 Uncharacterized membrane-associated protein/domain
 2  5  7  8 ||------------  13    [R]     COG2522 Predicted transcriptional regulator
 2  6  8  8 ||------------   8    [K]     COG2524 Predicted transcriptional regulator, contains C-terminal CBS domains
 2  3  4  7 |------------|   8    [R]     COG2603 Predicted ATPase
 2  3  5 12 ------------||  21    [R]     COG2704 Anaerobic C4-dicarboxylate transporter
 2  4  5 13 ------------||  13    [S]     COG2707 Predicted membrane protein
 2  4  4  8 ------------||   8    [K]     COG2732 Barstar, RNAse (barnase) inhibitor
 2  4  5 12 --------|---|-  12    [S]     COG2739 Uncharacterized protein conserved in bacteria
 2  8  8 10 |------|------  10    [C]     COG2811 Archaeal/vacuolar-type H+-ATPase subunit H
 2  5 10 20 ------|------|  21    [M]     COG2821 Membrane-bound lytic murein transglycosylase
 2  3  3  9 ------------||   9    [P]     COG2822 Predicted periplasmic lipoprotein involved in iron transport
 2  4  8 13 ------------||  13    [S]     COG2828 Uncharacterized protein conserved in bacteria
 2  4  6 10 -----------|-|  10    [C]     COG2838 Monomeric isocitrate dehydrogenase
 2  4 10 20 ----------|--|  25    [S]     COG2840 Uncharacterized protein conserved in bacteria
 2  4  9 20 -----------|-|  20    [O]     COG2844 UTP:GlnB (protein PII) uridylyltransferase
 2  4  4  8 ----------|--|   8    [S]     COG2845 Uncharacterized protein conserved in bacteria
 2  5  7 12 ------------||  12    [D]     COG2846 Regulator of cell morphogenesis and NO signaling
 2  3  7 13 ------------||  14    [S]     COG2850 Uncharacterized conserved protein
 2  5 11 18 --------|----|  20    [M]     COG2853 Surface lipoprotein
 2  5  9 12 -------|-----|  21    [C]     COG2863 Cytochrome c553
 2  5 12 21 --|----------|  21    [I]     COG2867 Oligoketide cyclase/lipid transport protein
 2  3  6  9 ---------|---|   9    [C]     COG2869 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC
 2  3  6  9 ---------|---|   9    [C]     COG2871 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF
 2  7  8 10 ||------------  11    [N    U]    COG2874 Predicted ATPases involved in biogenesis of archaeal flagella
 2  4  4  4 ||------------  18    [S]     COG2880 Uncharacterized protein conserved in archaea
 2  9 11 13 ||------------  13    [J]     COG2888 Predicted Zn-ribbon RNA-binding protein with a function in translation
 2  7  7  8 ||------------   8    [S]     COG2892 Uncharacterized protein conserved in archaea
 2  4  5  8 -----------|-|   9    [R]     COG2907 Predicted NAD/FAD-binding protein
 2  5 11 21 -----|-------|  23    [S]     COG2908 Uncharacterized protein conserved in bacteria
 2  5  7 11 ------------||  11    [R]     COG2910 Putative NADH-flavin reductase
 2  3  6 11 ------------||  11    [H]     COG2918 Gamma-glutamylcysteine synthetase
 2  2  4 10 --------|----|  10    [S]     COG2926 Uncharacterized protein conserved in bacteria
 2  5  8 10 ------|------|  13    [S]     COG2929 Uncharacterized protein conserved in bacteria
 2  6  9 12 --|----------|  12    [O]     COG2935 Putative arginyl-tRNA:protein arginylyltransferase
 2  2  6 13 -----------|-|  15    [I]     COG2937 Glycerol-3-phosphate O-acyltransferase
 2  5 12 22 --|----------|  22    [S]     COG2938 Uncharacterized conserved protein
 2  5  7  8 --|----------|   8    [H]     COG2941 Ubiquinone biosynthesis protein COQ7
 2  5  7 13 ------|------|  16    [G]     COG2942 N-acyl-D-glucosamine 2-epimerase
 2  4  8 13 ------|------|  20    [K]     COG2944 Predicted transcriptional regulator
 2  5  9 14 |------------|  14    [R]     COG2945 Predicted hydrolase of the alpha/beta superfamily
 2  3  4  5 ------------||  10    [L]     COG2946 Putative phage replication protein RstA
 2  4 10 20 -----------|-|  40    [M]     COG2951 Membrane-bound lytic murein transglycosylase B
 2  2  2  4 ----|--------|   4    [S]     COG2952 Uncharacterized protein conserved in bacteria
 2  5  5  8 ------|------|  10    [S]     COG2954 Uncharacterized protein conserved in bacteria
 2  4  8 15 -------|-----|  15    [P]     COG2967 Uncharacterized protein affecting Mg2+/Co2+ transport
 2  2  5 10 ---------|---|  10    [K]     COG2973 Trp operon repressor
 2  3  5 14 -----------|-|  14    [Q]     COG2977 Phosphopantetheinyl transferase component of siderophore synthetase
 2  3  6 14 ------|------|  14    [E]     COG2981 Uncharacterized protein involved in cysteine biosynthesis
 2  3  7 15 |------------|  15    [S]     COG2983 Uncharacterized conserved protein
 2  3  5  9 ------|------|   9    [E]     COG2988 Succinylglutamate desuccinylase
 2  3  4  7 --------|----|   7    [R]     COG2992 Uncharacterized FlgJ-related protein
 2  4  5  5 ------|------|   6    [O]     COG2994 ACP:hemolysin acyltransferase (hemolysin-activating protein)
 2  2  5  5 ------------||   7    [S]     COG3007 Uncharacterized paraquat-inducible protein B
 2  2  4  8 |------------|   8    [S]     COG3013 Uncharacterized conserved protein
 2  2  3  6 ----------|--|   6    [M    P]    COG3015 Uncharacterized lipoprotein NlpE involved in copper resistance
 2  3  4  4 ----|--------|   4    [S]     COG3016 Uncharacterized iron-regulated protein
 2  4 11 20 --------|----|  31    [V]     COG3023 Negative regulator of beta-lactamase expression
 2  4  8 13 |------------|  14    [S]     COG3025 Uncharacterized conserved protein
 2  2  4 10 -----------|-|  10    [C]     COG3029 Fumarate reductase subunit C
 2  2  3  3 ----|--------|   4    [U]     COG3031 Type II secretory pathway, component PulC
 2  4  6 15 ----|--------|  18    [S]     COG3034 Uncharacterized protein conserved in bacteria
 2  4 11 18 ------|------|  37    [C]     COG3038 Cytochrome B561
 2  4  7 11 -----------|-|  16    [M]     COG3040 Bacterial lipocalin
 2  4  6 11 |------------|  12    [R]     COG3042 Putative hemolysin
 2  3  5 10 --------|----|  13    [S]     COG3055 Uncharacterized protein conserved in bacteria
 2  3  5 10 ----|--------|  10    [O]     COG3058 Uncharacterized protein involved in formate dehydrogenase formation
 2  5 12 19 ------------||  20    [K]     COG3070 Regulator of competence-specific genes
 2  2  4  9 |------------|   9    [E]     COG3075 Anaerobic glycerol-3-phosphate dehydrogenase
 2  2  4 10 -----------|-|  10    [C]     COG3080 Fumarate reductase subunit D
 2  3  7 15 -------|-----|  22    [O]     COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes
 2  2  6 16 ------------||  16    [S]     COG3091 Uncharacterized protein conserved in bacteria
 2  2  5 11 ------------||  15    [T]     COG3103 SH3 domain protein
 2  4  9 20 -----------|-|  21    [O]     COG3118 Thioredoxin domain-containing protein
 2  4  7 17 ------------||  20    [C]     COG3125 Heme/copper-type cytochrome/quinol oxidase, subunit 4
 2  2  4  8 --|----------|   8    [R]     COG3129 Predicted SAM-dependent methyltransferase
 2  5  7 10 ------|------|  10    [S]     COG3146 Uncharacterized protein conserved in bacteria
 2  3  7 13 ------------||  30    [S]     COG3152 Predicted membrane protein
 2  5  9 14 ------|------|  15    [N    U]    COG3166 Tfp pilus assembly protein PilN
 2  3  5  6 -------|-----|   6    [S]     COG3169 Uncharacterized protein conserved in bacteria
 2  5  7 11 --|----------|  11    [O]     COG3175 Cytochrome oxidase assembly factor
 2  3  5  5 -------|-----|   8    [R]     COG3179 Predicted chitinase
 2  4  6  6 ---------|---|   6    [E]     COG3186 Phenylalanine-4-hydroxylase
 2  4  7 12 ------|------|  70    [N    U]    COG3188 P pilus assembly protein, porin PapC
 2  4  5 11 --|----------|  13    [F]     COG3194 Ureidoglycolate hydrolase
 2  2  3  4 -----------|-|   4    [S]     COG3196 Uncharacterized protein conserved in bacteria
 2  4  5 13 -----------|-|  15    [E]     COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase
 2  2  3  6 ------|------|  12    [S]     COG3204 Uncharacterized protein conserved in bacteria
 2  4  5  5 |------------|   6    [S]     COG3205 Predicted membrane protein
 2  2  3  3 --|----------|   3    [Q]     COG3207 Pyoverdine/dityrosine biosynthesis protein
 2  3  4  7 ------|------|   8    [S]     COG3216 Uncharacterized protein conserved in bacteria
 2  4  7  9 ------------||  11    [S]     COG3220 Uncharacterized protein conserved in bacteria
 2  2  5 10 ------------||  10    [S]     COG3223 Predicted membrane protein
 2  2  3  7 -----------|-|   9    [S]     COG3226 Uncharacterized protein conserved in bacteria
 2  4  5  9 ------|------|   9    [S]     COG3228 Uncharacterized protein conserved in bacteria
 2  4  4  5 -------|-----|   6    [P]     COG3230 Heme oxygenase
 2  4  7  8 -------|-----|   9    [E]     COG3232 5-carboxymethyl-2-hydroxymuconate isomerase
 2  3  4  6 -----|-------|   6    [S]     COG3234 Uncharacterized protein conserved in bacteria
 2  3  7  7 ------|------|   9    [I    R]    COG3240 Phospholipase/lecithinase/hemolysin
 2  3  4 10 -------|-----|  10    [R]     COG3257 Uncharacterized protein, possibly involved in glyoxylate utilization
 2  5  5  5 ------|------|   7    [C]     COG3258 Cytochrome c
 2  8  8  9 |-----|-------  16    [C]     COG3259 Coenzyme F420-reducing hydrogenase, alpha subunit
 2  4  7 15 ------|------|  24    [M]     COG3264 Small-conductance mechanosensitive channel
 2  2  4  5 -----------|-|   9    [U]     COG3267 Type II secretory pathway, component ExeA (predicted ATPase)
 2  8  8  9 ||------------  20    [R]     COG3269 Predicted RNA-binding protein, contains TRAM domain
 2  5  6  7 |------------|  18    [R]     COG3271 Predicted double-glycine peptidase
 2  3  5  9 |------------|   9    [S]     COG3272 Uncharacterized conserved protein
 2  7  7  8 ||------------  10    [S]     COG3273 Uncharacterized conserved protein
 2  4  5  9 ------------||  10    [S]     COG3274 Uncharacterized protein conserved in bacteria
 2  4  5  6 ||------------   6    [S]     COG3286 Uncharacterized protein conserved in archaea
 2  3  4  4 ------|------|   5    [T]     COG3292 Predicted periplasmic ligand-binding sensor domain
 2  4  5  5 -------|-----|   5    [S]     COG3295 Uncharacterized protein conserved in bacteria
 2  3  5  8 ------------||  13    [S]     COG3299 Uncharacterized homolog of phage Mu protein gp47
 2  3  4  9 ----|--------|  19    [R]     COG3302 DMSO reductase anchor subunit
 2  3  5 11 -----------|-|  11    [S]     COG3304 Predicted membrane protein
 2  2  3  4 -----------|-|   4    [S]     COG3305 Predicted membrane protein
 2  4  7  7 |------------|  12    [T]     COG3322 Predicted periplasmic ligand-binding sensor domain
 2  6  6  6 ||------------  20    [K]     COG3355 Predicted transcriptional regulator
 2  6  7  8 ||------------   8    [S]     COG3356 Predicted membrane protein
 2  5  6  6 ||------------   6    [K]     COG3357 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon
 2  5  5  6 |-----------|-   6    [L]     COG3359 Predicted exonuclease
 2  4  4  6 ||------------   7    [R]     COG3368 Predicted permease
 2  3  5  6 ||------------   8    [S]     COG3370 Uncharacterized protein conserved in archaea
 2  3  5  7 ||------------  12    [S]     COG3371 Predicted membrane protein
 2  4  4  6 |-----------|-   6    [S]     COG3377 Uncharacterized conserved protein
 2  3  4  4 ||------------   5    [S]     COG3379 Uncharacterized conserved protein
 2  3  4 10 ------------||  12    [S]     COG3394 Uncharacterized protein conserved in bacteria
 2  2  5  6 ------------||   7    [S]     COG3397 Uncharacterized protein conserved in bacteria
 2  2  2  4 ----|--------|   4    [S]     COG3400 Uncharacterized protein conserved in bacteria
 2  2  2  5 ------------||   8    [R]     COG3401 Fibronectin type 3 domain-containing protein
 2  4  5  6 ||------------  35    [R]     COG3413 Predicted DNA binding protein
 2  4  5  7 -|-----------|   7    [P]     COG3420 Nitrous oxidase accessory protein
 2  4  4  4 ------------||   5    [S]     COG3421 Uncharacterized protein conserved in bacteria
 2  4  7 13 |------------|  15    [S]     COG3422 Uncharacterized conserved protein
 2  5  7  8 ||------------  16    [K]     COG3432 Predicted transcriptional regulator
 2  3  4 11 ------------||  11    [R]     COG3443 Predicted periplasmic or secreted protein
 2  4  5  9 ------|------|  12    [T]     COG3447 Predicted integral membrane sensor domain
 2  4  4  6 ------|------|   6    [T]     COG3448 CBS-domain-containing membrane protein
 2  5  6 11 ------------||  17    [L]     COG3449 DNA gyrase inhibitor
 2  4  4  5 ------|------|   5    [T]     COG3452 Predicted periplasmic ligand-binding sensor domain
 2  3  4 10 ------|------|  14    [P]     COG3454 Metal-dependent hydrolase involved in phosphonate metabolism
 2  3  3  4 |----|--------   5    [S]     COG3462 Predicted membrane protein
 2  3  3  5 |-----|-------   7    [S]     COG3463 Predicted membrane protein
 2  3  3  5 |-----------|-   5    [S]     COG3465 Uncharacterized conserved protein
 2  2  4  4 ------------||   4    [G]     COG3469 Chitinase
 2  3  5  9 --|----------|  21    [C]     COG3474 Cytochrome c2
 2  3  4  7 ------------||   7    [S]     COG3477 Predicted periplasmic/secreted protein
 2  2  3  3 ------------||   3    [Q]     COG3479 Phenolic acid decarboxylase
 2  2  3 10 -----------||-  11    [T]     COG3480 Predicted secreted protein containing a PDZ domain
 2  4  5  5 -------|-----|   6    [E]     COG3483 Tryptophan 2,3-dioxygenase (vermilion)
 2  4  4  4 ------|------|   4    [O]     COG3484 Predicted proteasome-type protease
 2  4  7 11 -----------|-|  26    [Q]     COG3485 Protocatechuate 3,4-dioxygenase beta subunit
 2  5  7  7 --|----------|  11    [R]     COG3491 Isopenicillin N synthase and related dioxygenases
 2  3  4  6 -----------|-|   6    [S]     COG3496 Uncharacterized conserved protein
 2  4  6 10 ------|------|  12    [R]     COG3497 Phage tail sheath protein FI
 2  4  6 10 ------|------|  12    [R]     COG3500 Phage protein D
 2  4  6 10 ------|------|  45    [S]     COG3501 Uncharacterized protein conserved in bacteria
 2  6  7 10 |------------|  10    [S]     COG3503 Predicted membrane protein
 2  4  6  7 ------------||  14    [G]     COG3507 Beta-xylosidase
 2  4  6  7 -|-----------|   7    [Q]     COG3508 Homogentisate 1,2-dioxygenase
 2  4  5 10 -----------|-|  12    [Q]     COG3509 Poly(3-hydroxybutyrate) depolymerase
 2  4  4  4 ------------||   4    [S]     COG3512 Uncharacterized protein conserved in bacteria
 2  4  5  5 ------------||   5    [S]     COG3513 Uncharacterized protein conserved in bacteria
 2  3  5  7 ------------||   8    [G]     COG3525 N-acetyl-beta-hexosaminidase
 2  3  5  6 ------|------|   8    [R]     COG3549 Plasmid maintenance system killer protein
 2  3  3  3 ------------||   3    [S]     COG3551 Uncharacterized protein conserved in bacteria
 2  3  3  5 -----------|-|   6    [S]     COG3554 Uncharacterized protein conserved in bacteria
 2  4  6  7 ------|------|  11    [O]     COG3555 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases
 2  4  4  4 ------|------|   4    [S]     COG3556 Predicted membrane protein
 2  3  3  4 ------|------|   4    [S]     COG3558 Uncharacterized protein conserved in bacteria
 2  2  3  5 -----------||-   5    [M]     COG3559 Putative exporter of polyketide antibiotics
 2  4  6  8 ------------||  11    [K]     COG3561 Phage anti-repressor protein
 2  3  3  4 ------|------|   4    [R]     COG3565 Predicted dioxygenase of extradiol dioxygenase family
 2  3  4  4 ------------||   5    [S]     COG3566 Uncharacterized protein conserved in bacteria
 2  3  4  4 ------------||   5    [S]     COG3567 Uncharacterized protein conserved in bacteria
 2  4  8 15 ------------||  21    [R]     COG3568 Metal-dependent hydrolase
 2  3  3  5 -------|-----|   5    [V]     COG3570 Streptomycin 6-kinase
 2  3  3  5 -----------|-|   5    [R]     COG3571 Predicted hydrolase of the alpha/beta-hydrolase fold
 2  4  4  4 |-|-----------   7    [R]     COG3582 Predicted nucleic acid binding protein containing the AN1-type Zn-finger
 2  3  3  8 -----------||-   8    [S]     COG3583 Uncharacterized protein conserved in bacteria
 2  4  5  7 |------------|   7    [S]     COG3586 Uncharacterized conserved protein
 2  4  5  7 --------|----|   8    [V]     COG3587 Restriction endonuclease
 2  3  4 10 ------------||  18    [E]     COG3591 V8-like Glu-specific endopeptidase
 2  5  6  8 ------|------|  12    [R]     COG3596 Predicted GTPase
 2  5  6  9 |------------|  15    [R]     COG3608 Predicted deacylase
 2  3  4 10 ------------||  11    [P]     COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance
 2  3  7 10 ------------||  21    [K]     COG3617 Prophage antirepressor
 2  4  6 13 -----------|-|  21    [G]     COG3622 Hydroxypyruvate isomerase
 2  3  5 12 ------------||  14    [G]     COG3623 Putative L-xylulose-5-phosphate 3-epimerase
 2  3  4  9 ------|------|  11    [P]     COG3624 Uncharacterized enzyme of phosphonate metabolism
 2  3  4  9 ------|------|  11    [P]     COG3625 Uncharacterized enzyme of phosphonate metabolism
 2  3  4  9 ------|------|  11    [P]     COG3626 Uncharacterized enzyme of phosphonate metabolism
 2  3  4  9 ------|------|  11    [P]     COG3627 Uncharacterized enzyme of phosphonate metabolism
 2  4  6  7 ------|------|   9    [R]     COG3628 Phage baseplate assembly protein W
 2  4  7 13 ------------||  13    [E]     COG3633 Na+/serine symporter
 2  4  7 12 ------------||  12    [O]     COG3634 Alkyl hydroperoxide reductase, large subunit
 2  4  4  4 -------|-----|   4    [S]     COG3644 Uncharacterized protein conserved in bacteria
 2  2  3  8 ------------||  13    [S]     COG3645 Uncharacterized phage-encoded protein
 2  2  4  8 ------------||  10    [S]     COG3646 Uncharacterized phage-encoded protein
 2  2  3  3 -----|------|-   3    [L]     COG3649 Uncharacterized protein predicted to be involved in DNA repair
 2  3  4  4 ------|------|   4    [S]     COG3650 Predicted membrane protein
 2  3  4  5 -------|-----|   7    [S]     COG3652 Predicted outer membrane protein
 2  3  3  3 -------|-----|   3    [S]     COG3656 Predicted periplasmic protein
 2  4  7  7 ------|------|  10    [S]     COG3657 Uncharacterized protein conserved in bacteria
 2  4  4  4 ------|------|   6    [M]     COG3659 Carbohydrate-selective porin
 2  4  4  5 -----------|-|  11    [S]     COG3662 Uncharacterized protein conserved in bacteria
 2  3  4  6 ------------||   6    [G]     COG3664 Beta-xylosidase
 2  3  3  3 --|----------|   3    [S]     COG3673 Uncharacterized conserved protein
 2  3  3  4 |------------|  30    [L]     COG3676 Transposase and inactivated derivatives
 2  5  8 12 ------|------|  21    [U    N    T    P]    COG3678 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein
 2  3  4  9 |-----------|-  13    [S]     COG3679 Uncharacterized conserved protein
 2  3  3  5 -------|-----|   5    [S]     COG3680 Uncharacterized protein conserved in bacteria
 2  3  4  9 ------------||  10    [G]     COG3684 Tagatose-1,6-bisphosphate aldolase
 2  3  4  9 ------|------|  23    [S]     COG3685 Uncharacterized protein conserved in bacteria
 2  4  6  8 ------|------|   8    [S]     COG3686 Predicted membrane protein
 2  4  4  5 -----------|-|   7    [R]     COG3687 Predicted metal-dependent hydrolase
 2  4  5  8 ------|-----|-   8    [R]     COG3688 Predicted RNA-binding protein containing a PIN domain
 2  4  5  8 ------|-----|-   8    [S]     COG3689 Predicted membrane protein
 2  3  3  8 -------|-----|   8    [S]     COG3698 Predicted periplasmic protein
 2  2  3  6 ------------||   6    [R]     COG3700 Acid phosphatase (class B)
 2  4  7 13 --------|----|  20    [M]     COG3713 Outer membrane protein V
 2  4  6 12 -----------|-|  13    [S]     COG3714 Predicted membrane protein
 2  3  4 10 ------------||  11    [G]     COG3717 5-keto 4-deoxyuronate isomerase
 2  2  3  9 ------------||  10    [L]     COG3723 Recombinational DNA repair protein (RecE pathway)
 2  3  5 10 ------------||  16    [L]     COG3728 Phage terminase, small subunit
 2  3  4  8 ------------||  10    [G]     COG3730 Phosphotransferase system sorbitol-specific component IIC
 2  3  4  8 ------------||   9    [G]     COG3731 Phosphotransferase system sorbitol-specific component IIA
 2  3  4  7 ------------||   9    [G]     COG3732 Phosphotransferase system sorbitol-specific component IIBC
 2  3  5  7 ------------||   7    [S]     COG3739 Uncharacterized integral membrane protein
 2  3  5  8 -------|-----|  13    [E]     COG3741 N-formylglutamate amidohydrolase
 2  2  3  5 -----------|-|  15    [S]     COG3742 Uncharacterized protein conserved in bacteria
 2  2  3  6 |------------|  10    [S]     COG3743 Uncharacterized conserved protein
 2  2  3  5 ------------||   8    [M]     COG3754 Lipopolysaccharide biosynthesis protein
 2  4  5 12 ------------||  23    [M]     COG3757 Lyzozyme M1 (1,4-beta-N-acetylmuramidase)
 2  3  4  7 ------------||   7    [S]     COG3760 Uncharacterized conserved protein
 2  4  5  6 ----------|--|   6    [S]     COG3762 Predicted membrane protein
 2  4  5  9 ------------||  10    [S]     COG3766 Predicted membrane protein
 2  3  4  8 ------------||  17    [M]     COG3773 Cell wall hydrolyses involved in spore germination
 2  3  4 10 ------------||  17    [G]     COG3775 Phosphotransferase system, galactitol-specific IIC component
 2  4  5  5 --|----------|   5    [S]     COG3777 Uncharacterized conserved protein
 2  4  4  5 ||------------   6    [L]     COG3780 DNA endonuclease related to intein-encoded endonucleases
 2  5  5  8 ------|------|   8    [S]     COG3781 Predicted membrane protein
 2  3  4  8 ------|------|   8    [R]     COG3788 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily
 2  4  6  9 --|----------|  43    [S]     COG3791 Uncharacterized conserved protein
 2  2  3  3 -------|-----|   4    [S]     COG3798 Uncharacterized protein conserved in bacteria
 2  3  3  4 |------------|   5    [E]     COG3799 Methylaspartate ammonia-lyase
 2  2  3  8 -----------|-|  14    [R]     COG3800 Predicted transcriptional regulator
 2  2  3  4 -----------|-|   5    [S]     COG3801 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------|------|   3    [Q]     COG3805 Aromatic ring-cleaving dioxygenase
 2  3  4  4 -|-----------|   4    [S]     COG3809 Uncharacterized protein conserved in bacteria
 2  5  5  6 ------------||   6    [S]     COG3817 Predicted membrane protein
 2  5  5  6 ------------||   6    [S]     COG3819 Predicted membrane protein
 2  3  4  7 ------------||   7    [R]     COG3822 ABC-type sugar transport system, auxiliary component
 2  2  3  7 -----------|-|   7    [S]     COG3824 Uncharacterized protein conserved in bacteria
 2  4  5  5 ------|------|   5    [S]     COG3825 Uncharacterized protein conserved in bacteria
 2  3  4  5 -----------|-|   5    [S]     COG3826 Uncharacterized protein conserved in bacteria
 2  2  3  5 ------------||   5    [S]     COG3828 Uncharacterized protein conserved in bacteria
 2  3  6 11 ------------||  11    [K    T]    COG3835 Sugar diacid utilization regulator
 2  5  5  7 ------------||  12    [U]     COG3843 Type IV secretory pathway, VirD2 components (relaxase)
 2  4  4  5 ------|-----|-   5    [S]     COG3854 Uncharacterized protein conserved in bacteria
 2  3  4  6 --------|---|-   6    [G]     COG3855 Uncharacterized protein conserved in bacteria
 2  3  3  5 -----------||-   5    [S]     COG3856 Uncharacterized conserved protein (small basic protein)
 2  3  3  4 ------------||  10    [R]     COG3858 Predicted glycosyl hydrolase
 2  3  3  3 |-----------|-   3    [S]     COG3863 Uncharacterized distant relative of cell wall-associated hydrolases
 2  3  3  4 -----|------|-   6    [G]     COG3866 Pectate lyase
 2  3  3  7 ---------|--|-   7    [E]     COG3869 Arginine kinase
 2  3  3  6 -------|----|-   7    [S]     COG3870 Uncharacterized protein conserved in bacteria
 2  4  4  5 |-----------|-   6    [S]     COG3874 Uncharacterized conserved protein
 2  3  3  5 ---------|--|-   5    [S]     COG3876 Uncharacterized protein conserved in bacteria
 2  3  3  5 -----------||-  12    [S]     COG3879 Uncharacterized protein conserved in bacteria
 2  3  3  7 ---------|--|-   7    [S]     COG3880 Uncharacterized protein with conserved CXXC pairs
 2  3  3  4 -------|----|-   4    [S]     COG3881 Uncharacterized protein conserved in bacteria
 2  4  4  4 ------------||   7    [Q]     COG3882 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis
 2  3  3  7 -----------||-   9    [I]     COG3884 Acyl-ACP thioesterase
 2  3  3  4 ||------------   4    [K]     COG3888 Predicted transcriptional regulator
 2  2  4  5 ||------------   5    [R]     COG3889 Predicted solute binding protein
 2  3  3  4 |------------|   8    [R]     COG3894 Uncharacterized metal-binding protein
 2  4  5 11 ------|------|  11    [R]     COG3895 Predicted periplasmic protein
 2  2  2  4 -----------|-|   4    [V]     COG3896 Chloramphenicol 3-O-phosphotransferase
 2  4  5  8 --|----------|  11    [R]     COG3897 Predicted methyltransferase
 2  2  2  3 ------|------|   4    [S]     COG3900 Predicted periplasmic protein
 2  2  2  5 -----------|-|  17    [R]     COG3903 Predicted ATPase
 2  3  4  9 -----|------|-   9    [S]     COG3906 Uncharacterized protein conserved in bacteria
 2  3  4  4 ------|------|   7    [O]     COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family
 2  2  2  4 -----------|-|   4    [S]     COG3918 Predicted membrane protein
 2  2  2  3 ------------||   3    [R]     COG3919 Predicted ATP-grasp enzyme
 2  3  4  5 ------|------|   7    [R]     COG3932 Uncharacterized ABC-type transport system, permease components
 2  3  3  4 ------------||   7    [K]     COG3933 Transcriptional antiterminator
 2  3  3  3 ------------||   3    [R]     COG3940 Predicted beta-xylosidase
 2  2  3  5 ------------||  20    [R]     COG3942 Surface antigen
 2  3  4  6 -----------||-   9    [M]     COG3944 Capsular polysaccharide biosynthesis protein
 2  3  3  3 -------|----|-   4    [T]     COG3947 Response regulator containing CheY-like receiver and SARP domains
 2  3  5 10 ----------|--|  11    [M    N    O]    COG3951 Rod binding protein
 2  3  3  5 ---------|---|   5    [S]     COG3952 Predicted membrane protein
 2  3  4  6 -----------||-   9    [R]     COG3953 SLT domain proteins
 2  3  3  3 ------------||   4    [M]     COG3955 Exopolysaccharide biosynthesis protein
 2  3  3  6 ------------||   7    [I]     COG3963 Phospholipid N-methyltransferase
 2  3  4  5 ------------||   5    [P]     COG3965 Predicted Co/Zn/Cd cation transporters
 2  3  5  9 ------------||  12    [R]     COG3969 Predicted phosphoadenosine phosphosulfate sulfotransferase
 2  3  4  6 -|-----------|   6    [R]     COG3970 Fumarylacetoacetate (FAA) hydrolase family protein
 2  3  4  9 ------|------|   9    [E]     COG3977 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase
 2  2  4  4 ||------------   4    [S]     COG4006 Uncharacterized protein conserved in archaea
 2  5  5  5 |-|-----------   5    [S]     COG4021 Uncharacterized conserved protein
 2  4  5  6 ||------------   6    [U]     COG4023 Preprotein translocase subunit Sec61beta
 2  3  3  4 ||------------   4    [S]     COG4027 Uncharacterized protein conserved in archaea
 2  3  4  5 ||------------   5    [R]     COG4028 Predicted P-loop ATPase/GTPase
 2  3  5  5 ||------------   5    [S]     COG4034 Uncharacterized protein conserved in archaea
 2  3  3  4 |-----------|-   6    [S]     COG4043 Uncharacterized conserved protein
 2  3  5  5 ||------------   5    [S]     COG4046 Uncharacterized protein conserved in archaea
 2  3  4  5 ||------------   5    [S]     COG4047 Uncharacterized protein conserved in archaea
 2  2  3  3 |------------|   8    [O]     COG4067 Uncharacterized protein conserved in archaea
 2  3  5  5 ||------------   6    [L]     COG4080 RecB-family nuclease
 2  4  4  5 |-----------|-   5    [R]     COG4085 Predicted RNA-binding protein, contains TRAM domain
 2  4  5  6 |-----------|-   6    [S]     COG4086 Predicted secreted protein
 2  4  4  4 |-|-----------   4    [F]     COG4088 Predicted nucleotide kinase
 2  4  5  5 ||------------   5    [S]     COG4089 Predicted membrane protein
 2  3  4  5 ------|------|   7    [S]     COG4094 Predicted membrane protein
 2  3  4  4 -----|-------|   4    [R]     COG4099 Predicted peptidase
 2  4  4  7 ------|-----|-   7    [P]     COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance
 2  5 12 25 ----|--------|  25    [R]     COG4105 DNA uptake lipoprotein
 2  3  4  9 ------|------|  11    [P]     COG4107 ABC-type phosphonate transport system, ATPase component
 2  2  2  3 -----|------|-   3    [R]     COG4112 Predicted phosphoesterase (MutT family)
 2  3  3  7 ------------||   7    [R]     COG4114 Uncharacterized Fe-S protein
 2  4  5  9 ------|------|   9    [C]     COG4117 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein)
 2  2  2  4 -----------|-|   4    [L    R]    COG4119 Predicted NTP pyrophosphohydrolase
 2  3  3  6 ------------||  10    [G]     COG4124 Beta-mannanase
 2  2  3  6 ------------||   6    [R]     COG4146 Predicted symporter
 2  3  6 14 ------------||  14    [P]     COG4148 ABC-type molybdate transport system, ATPase component
 2  3  4 10 ------------||  12    [G]     COG4154 Fucose dissimilation pathway protein FucU
 2  4  6 13 --------|----|  23    [R]     COG4172 ABC-type uncharacterized transport system, duplicated ATPase component
 2  2  2  4 ------------||   4    [K]     COG4189 Predicted transcriptional regulator
 2  3  3  3 |------------|   6    [K]     COG4190 Predicted transcriptional regulator
 2  2  2  5 -----------|-|   5    [S]     COG4196 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------------||   6    [S]     COG4200 Uncharacterized protein conserved in bacteria
 2  2  3  7 ------------||  14    [G]     COG4209 ABC-type polysaccharide transport system, permease component
 2  5  6 12 ------------||  18    [G]     COG4213 ABC-type xylose transport system, periplasmic component
 2  5  6 12 ------------||  17    [G]     COG4214 ABC-type xylose transport system, permease component
 2  3  3  3 ------------||   7    [K    T]    COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component
 2  3  4  9 --------|---|-  11    [S]     COG4224 Uncharacterized protein conserved in bacteria
 2  4  4  6 ------------||   9    [R]     COG4225 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins
 2  5 10 17 ---------|---|  19    [O    C]    COG4232 Thiol:disulfide interchange protein
 2  3  4  8 ---------|---|   8    [O    C]    COG4233 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis
 2  5  7 15 ----------|--|  16    [R]     COG4239 ABC-type uncharacterized transport system, permease component
 2  4  4  6 ------|-----|-   6    [S]     COG4241 Predicted membrane protein
 2  3  3  3 ------|------|   5    [Q    P]    COG4242 Cyanophycinase and related exopeptidases
 2  3  3  6 ------|------|   8    [R]     COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain
 2  3  3  3 ------|------|  15    [R]     COG4249 Uncharacterized protein containing caspase domain
 2  3  3  3 |-----|-------   4    [T]     COG4250 Predicted sensor protein/domain
 2  3  3  3 ------|------|   4    [V]     COG4257 Streptogramin lyase
 2  2  3  4 ------------||   4    [S]     COG4260 Putative virion core protein (lumpy skin disease virus)
 2  5  5  5 --|----------|   5    [F]     COG4266 Allantoicase
 2  4  4  9 -------|-----|   9    [S]     COG4269 Predicted membrane protein
 2  4  4  4 |------------|   5    [S]     COG4273 Uncharacterized conserved protein
 2  3  3  4 |------------|   5    [S]     COG4275 Uncharacterized conserved protein
 2  3  4  4 -----|-------|   4    [R]     COG4287 PhoPQ-activated pathogenicity-related protein
 2  3  3  4 -----|-------|   4    [S]     COG4289 Uncharacterized protein conserved in bacteria
 2  3  3  6 -------|-----|   6    [S]     COG4291 Predicted membrane protein
 2  3  3  4 ------------||   4    [S]     COG4304 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------------||   3    [G]     COG4305 Endoglucanase C-terminal domain/subunit and related proteins
 2  3  3  3 ------------||   3    [S]     COG4306 Uncharacterized protein conserved in bacteria
 2  3  3  5 -----------|-|   5    [S]     COG4307 Uncharacterized protein conserved in bacteria
 2  3  3  4 -----------|-|   5    [Q]     COG4308 Limonene-1,2-epoxide hydrolase
 2  3  3  4 ------------||   4    [R]     COG4310 Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain
 2  4  4  5 ------------||   5    [S]     COG4317 Uncharacterized protein conserved in bacteria
 2  4  4  4 ------------||   4    [S]     COG4331 Predicted membrane protein
 2  3  3  4 ------------||   4    [S]     COG4332 Uncharacterized protein conserved in bacteria
 2  3  3  4 ------------||   4    [S]     COG4333 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------------||   3    [S]     COG4334 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------------||   4    [L]     COG4335 DNA alkylation repair enzyme
 2  3  3  3 ------|------|   3    [S]     COG4337 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------|------|   3    [S]     COG4338 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------|------|   3    [S]     COG4339 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------|------|   3    [S]     COG4340 Uncharacterized protein conserved in bacteria
 2  4  4  4 ------|------|   5    [R]     COG4341 Predicted HD phosphohydrolase
 2  2  3  3 ||------------   5    [S]     COG4342 Uncharacterized protein conserved in archaea
 2  2  4  4 ||------------   6    [S]     COG4343 Uncharacterized protein conserved in archaea
 2  3  3  4 ||------------   4    [S]     COG4344 Uncharacterized protein conserved in archaea
 2  2  4  5 ||------------   5    [S]     COG4345 Uncharacterized protein conserved in archaea
 2  2  4  5 ||------------   5    [O]     COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase
 2  2  2  5 |-----------|-   5    [S]     COG4347 Predicted membrane protein
 2  2  4  4 -|--|---------   4    [S]     COG4353 Uncharacterized conserved protein
 2  3  3  3 -|----|-------   6    [G]     COG4354 Predicted bile acid beta-glucosidase
 2  3  4  5 --|---------|-   5    [S]     COG4357 Uncharacterized conserved protein
 2  4  4  4 --|---------|-   4    [E]     COG4359 Uncharacterized conserved protein, possibly involved in methylthioadenosine recycling
 2  3  3  3 --|---|-------   4    [F]     COG4360 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II)
 2  2  2  4 -------|----|-   4    [P    E]    COG4362 Nitric oxide synthase, oxygenase domain
 2  2  2  4 -------|----|-   4    [S]     COG4365 Uncharacterized protein conserved in bacteria
 2  2  3  4 -------|----|-   4    [S]     COG4367 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------||------   4    [S]     COG4370 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------||------   3    [S]     COG4371 Predicted membrane protein
 2  3  3  3 ------||------   3    [S]     COG4372 Uncharacterized protein conserved in bacteria with the myosin-like domain
 2  2  3  3 -------|-----|   3    [R]     COG4373 Mu-like prophage FluMu protein gp28
 2  2  3  3 -------|-----|   3    [S]     COG4374 Uncharacterized protein conserved in bacteria
 2  2  3  3 ------------||   3    [S]     COG4377 Predicted membrane protein
 2  3  3  3 ------------||   3    [S]     COG4378 Uncharacterized protein conserved in bacteria
 2  3  4  4 --------|----|   4    [S]     COG4393 Predicted membrane protein
 2  3  4  4 --------|----|   4    [S]     COG4394 Uncharacterized protein conserved in bacteria
 2  3  3  4 ------|----|--   6    [S]     COG4398 Uncharacterized protein conserved in bacteria
 2  3  3  5 ------|-----|-   5    [E]     COG4401 Chorismate mutase
 2  3  3  4 ------|----|--   4    [S]     COG4402 Uncharacterized protein conserved in bacteria
 2  3  4  5 ------|-----|-   7    [V]     COG4403 Lantibiotic modifying enzyme
 2  3  4  9 ------------||   9    [S]     COG4405 Uncharacterized protein conserved in bacteria
 2  2  3  4 ------------||   4    [S]     COG4408 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------------||   3    [S]     COG4412 Uncharacterized protein conserved in bacteria
 2  3  4  4 ------------||   4    [E]     COG4413 Urea transporter
 2  2  3  3 ------------||   3    [R]     COG4416 Mu-like prophage protein Com
 2  2  3  3 ------------||   5    [G]     COG4421 Capsular polysaccharide biosynthesis protein
 2  2  2  4 -----------|-|   5    [S]     COG4422 Bacteriophage protein gp37
 2  2  2  4 -----------|-|  14    [S]     COG4423 Uncharacterized protein conserved in bacteria
 2  2  2  4 -----------|-|   5    [S]     COG4424 Uncharacterized protein conserved in bacteria
 2  2  2  6 -----------|-|   6    [S]     COG4425 Predicted membrane protein
 2  2  3  5 -----------|-|   5    [S]     COG4427 Uncharacterized protein conserved in bacteria
 2  3  4  6 ----------|-|-   6    [S]     COG4443 Uncharacterized protein conserved in bacteria
 2  2  4  4 ------|------|   4    [F    J]    COG4445 Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA
 2  3  3  3 ------|------|   4    [S]     COG4446 Uncharacterized protein conserved in bacteria
 2  4  4  4 ------|------|   4    [R]     COG4447 Uncharacterized protein related to plant photosystem II stability/assembly factor
 2  3  3  6 ------|------|   6    [E]     COG4448 L-asparaginase II
 2  3  3  3 ------|------|   3    [R]     COG4449 Predicted protease of the Abi (CAAX) family
 2  3  3  3 ------|------|   6    [C]     COG4451 Ribulose bisphosphate carboxylase small subunit
 2  3  4  8 --------|----|   8    [V]     COG4452 Inner membrane protein involved in colicin E2 resistance
 2  4  7 10 -----------|-|  17    [S]     COG4453 Uncharacterized protein conserved in bacteria
 2  3  6  7 ------|------|  12    [S]     COG4456 Virulence-associated protein and related proteins
 2  3  4  7 -----------|-|   8    [S]     COG4461 Uncharacterized protein conserved in bacteria, putative lipoprotein
 2  3  4  6 --------|---|-   7    [G]     COG4468 Galactose-1-phosphate uridyltransferase
 2  4  4  9 ------------||  11    [S]     COG4487 Uncharacterized protein conserved in bacteria
 2  3  3  5 --------|---|-   5    [R]     COG4492 ACT domain-containing protein
 2  3  3  6 ------------||   6    [S]     COG4496 Uncharacterized protein conserved in bacteria
 2  4  9 17 ------------||  17    [P]     COG4536 Putative Mg2+ and Co2+ transporter CorB
 2  2  3  3 |------------|   3    [S]     COG4538 Uncharacterized conserved protein
 2  4  4  4 --|----------|   4    [S]     COG4539 Predicted membrane protein
 2  4  4  4 ------------||   5    [Q]     COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase
 2  3  3  6 ------------||   6    [P]     COG4548 Nitric oxide reductase activation protein
 2  2  2  6 ------------||   7    [S]     COG4549 Uncharacterized protein conserved in bacteria
 2  4  4  4 ------|------|   4    [R]     COG4551 Predicted protein tyrosine phosphatase
 2  3  3  6 -----------|-|   6    [Q]     COG4569 Acetaldehyde dehydrogenase (acetylating)
 2  3  3  6 ------|------|   7    [R]     COG4572 Putative cation transport regulator
 2  3  6  9 --------|----|   9    [R]     COG4589 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase
 2  2  3  4 ------------||   6    [P]     COG4594 ABC-type Fe3+-citrate transport system, periplasmic component
 2  3  4  9 ------|------|   9    [E]     COG4597 ABC-type amino acid transport system, permease component
 2  3  6  9 ----|--------|  18    [R]     COG4618 ABC-type protease/lipase transport system, ATPase and permease components
 2  3  3  6 ------------||   6    [R]     COG4619 ABC-type uncharacterized transport system, ATPase component
 2  4  5  6 --------|----|  11    [S]     COG4625 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain
 2  4  5  8 ------------||  19    [R]     COG4626 Phage terminase-like protein, large subunit
 2  2  3  3 -------|-----|   4    [S]     COG4628 Uncharacterized conserved protein
 2  4  4  7 -------|-----|   8    [F]     COG4630 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A
 2  4  5  8 -------|-----|   9    [F]     COG4631 Xanthine dehydrogenase, molybdopterin-binding subunit B
 2  3  3  3 ------|-----|-   4    [S]     COG4633 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------|------|   7    [S]     COG4634 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------|------|   5    [R]     COG4637 Predicted ATPase
 2  3  3  4 ------------||   8    [S]     COG4641 Uncharacterized protein conserved in bacteria
 2  4  5  8 -----------|-|  12    [R]     COG4653 Predicted phage phi-C31 gp36 major capsid-like protein
 2  3  3  3 ----|--------|   5    [C]     COG4654 Cytochrome c551/c552
 2  4  4  7 ------|------|  11    [Q]     COG4663 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component
 2  4  4  7 ------|------|   9    [Q]     COG4664 TRAP-type mannitol/chloroaromatic compound transport system, large permease component
 2  4  4  7 ------|------|   9    [Q]     COG4665 TRAP-type mannitol/chloroaromatic compound transport system, small permease component
 2  4  5  9 ---------|---|  13    [U]     COG4669 Type III secretory pathway, lipoprotein EscJ
 2  3  3  5 ------|------|  10    [R]     COG4671 Predicted glycosyl transferase
 2  3  3  3 ------|------|   7    [S]     COG4675 Microcystin-dependent protein
 2  3  3  7 ------------||   7    [G]     COG4677 Pectin methylesterase
 2  4  4  5 ------|------|   7    [G]     COG4678 Muramidase (phage lambda lysozyme)
 2  3  3  7 ------|------|   7    [S]     COG4680 Uncharacterized protein conserved in bacteria
 2  3  3  7 ------------||  10    [S]     COG4682 Predicted membrane protein
 2  3  3  3 ------------||   5    [Q]     COG4689 Acetoacetate decarboxylase
 2  3  3  4 -----------|-|   5    [R]     COG4691 Plasmid stability protein
 2  5  6 11 ------------||  21    [S]     COG4695 Phage-related protein
 2  2  2  4 -------|----|-   4    [S]     COG4696 Uncharacterized protein conserved in bacteria
 2  2  3  4 ||------------   5    [S]     COG4697 Uncharacterized protein conserved in archaea
 2  4  4  6 --|----------|   6    [S]     COG4702 Uncharacterized conserved protein
 2  3  3  3 ------|------|   4    [S]     COG4704 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------|------|   4    [S]     COG4705 Uncharacterized membrane-anchored protein conserved in bacteria
 2  3  4  6 ------------||   6    [S]     COG4709 Predicted membrane protein
 2  3  3  3 -------|----|-   3    [S]     COG4712 Uncharacterized protein conserved in bacteria
 2  3  4  7 |-----------|-  10    [S]     COG4720 Predicted membrane protein
 2  2  3  4 -----------||-   4    [S]     COG4721 Predicted membrane protein
 2  3  3  3 ------------||   3    [S]     COG4728 Uncharacterized protein conserved in bacteria
 2  4  5 10 ----------|--|  14    [S]     COG4731 Uncharacterized protein conserved in bacteria
 2  2  4  4 -|----------|-   4    [S]     COG4732 Predicted membrane protein
 2  3  3  3 ------|------|   3    [R]     COG4734 Antirestriction protein
 2  4  4  8 ------|------|  12    [S]     COG4735 Uncharacterized protein conserved in bacteria
 2  4  5  8 ------|------|   9    [S]     COG4737 Uncharacterized protein conserved in bacteria
 2  4  4  4 |------------|   6    [S]     COG4744 Uncharacterized conserved protein
 2  2  3  7 --------|---|-  16    [T]     COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain
 2  2  3  3 ||------------   3    [R]     COG4756 Predicted cation transporter
 2  4  4  4 -----------|-|   5    [R]     COG4757 Predicted alpha/beta hydrolase
 2  3  3  3 ------|----|--   9    [O]     COG4759 Uncharacterized protein conserved in bacteria containing thioredoxin-like domain
 2  2  2  5 -----------|-|   5    [S]     COG4760 Predicted membrane protein
 2  2  2  4 -------|---|--   5    [S]     COG4762 Uncharacterized protein conserved in bacteria
 2  3  3  5 -----------|-|   5    [S]     COG4763 Predicted membrane protein
 2  3  4  6 -----------||-  15    [V]     COG4767 Glycopeptide antibiotics resistance protein
 2  3  4  9 ------|------|  11    [P]     COG4778 ABC-type phosphonate transport system, ATPase component
 2  3  5  9 -----------|-|  10    [P]     COG4779 ABC-type enterobactin transport system, permease component
 2  3  3  6 ------|------|  12    [S]     COG4782 Uncharacterized protein conserved in bacteria
 2  4  5  9 ---------|---|  13    [U]     COG4789 Type III secretory pathway, component EscV
 2  4  5  9 ---------|---|  15    [U]     COG4791 Type III secretory pathway, component EscT
 2  4  5  9 ---------|---|  13    [U]     COG4794 Type III secretory pathway, component EscS
 2  4  4  6 --------|----|   8    [R]     COG4797 Predicted regulatory domain of a methyltransferase
 2  2  3  3 ------|------|   7    [R]     COG4798 Predicted methyltransferase
 2  5  5  5 |-----|-------   6    [C]     COG4802 Ferredoxin-thioredoxin reductase, catalytic subunit
 2  3  3  3 -----------|-|   8    [S]     COG4805 Uncharacterized protein conserved in bacteria
 2  2  2  8 ------------||   8    [G]     COG4806 L-rhamnose isomerase
 2  2  3  7 --------|----|   7    [S]     COG4807 Uncharacterized protein conserved in bacteria
 2  2  2  6 ------------||   7    [S]     COG4808 Uncharacterized protein conserved in bacteria
 2  2  3  7 ------------||   7    [S]     COG4811 Predicted membrane protein
 2  2  2  6 ------------||   6    [G]     COG4813 Trehalose utilization protein
 2  2  2  3 -----------||-   6    [S]     COG4815 Uncharacterized protein conserved in bacteria
 2  2  2  3 ------------||   5    [R]     COG4821 Uncharacterized protein containing SIS (Sugar ISomerase) phosphosugar binding domain
 2  2  2  5 -----------||-   5    [S]     COG4825 Uncharacterized membrane-anchored protein conserved in bacteria
 2  2  2  4 -----------|-|   4    [Q]     COG4829 Muconolactone delta-isomerase
 2  2  2  4 -----------||-   4    [G]     COG4833 Predicted glycosyl hydrolase
 2  3  3  3 ------------||   4    [S]     COG4834 Uncharacterized protein conserved in bacteria
 2  3  3  9 -----------||-  32    [S]     COG4842 Uncharacterized protein conserved in bacteria
 2  2  3  4 ||------------   4    [S]     COG4847 Uncharacterized protein conserved in archaea
 2  2  2  4 -----------|-|   4    [S]     COG4849 Uncharacterized protein conserved in bacteria
 2  2  3  4 ------------||   4    [S]     COG4852 Predicted membrane protein
 2  3  3  4 --------|----|   4    [S]     COG4859 Uncharacterized protein conserved in bacteria
 2  2  2  4 -----------|-|   4    [S]     COG4861 Uncharacterized protein conserved in bacteria
 2  2  2  4 -------|---|--   4    [R]     COG4867 Uncharacterized protein with a von Willebrand factor type A (vWA) domain
 2  3  3  3 --------|----|   3    [S]     COG4874 Uncharacterized protein conserved in bacteria containing a pentein-type domain
 2  3  3  3 ||------------   3    [R]     COG4880 Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats
 2  2  3  3 ||------------   3    [S]     COG4881 Predicted membrane protein
 2  3  3  3 |-----------|-   3    [R]     COG4892 Predicted heme/steroid binding protein
 2  2  3  3 ------------||   3    [S]     COG4898 Uncharacterized protein conserved in bacteria
 2  3  3  3 -----------|-|   3    [S]     COG4899 Uncharacterized protein conserved in bacteria
 2  2  3  3 ||------------   3    [S]     COG4904 Uncharacterized protein conserved in archaea
 2  3  3  3 |-------|-----   3    [S]     COG4907 Predicted membrane protein
 2  3  3  3 ------------||   3    [Q]     COG4909 Propanediol dehydratase, large subunit
 2  3  3  3 ------------||   3    [Q]     COG4910 Propanediol dehydratase, small subunit
 2  2  3  3 -|--|---------   3    [S]     COG4911 Uncharacterized conserved protein
 2  2  3  3 -----------|-|   3    [S]     COG4913 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------|------|   3    [S]     COG4916 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain
 2  2  3  3 -----------|-|   3    [S]     COG4924 Uncharacterized protein conserved in bacteria
 2  3  3  3 |------------|   3    [S]     COG4925 Uncharacterized conserved protein
 2  3  3  3 ------------||   3    [T    K]    COG4936 Predicted sensor domain
 2  2  3 10 ------------||  10    [U]     COG4940 Competence protein ComGF
 2  4  9 18 --------|----|  18    [D]     COG4942 Membrane-bound metallopeptidase
 2  3  3  3 ||------------   4    [G]     COG4945 Membrane-anchored protein predicted to be involved in regulation of amylopullulanase
 2  2  3  4 ||------------   4    [S]     COG4946 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system
 2  2  2  3 ------------||   4    [S]     COG4947 Uncharacterized protein conserved in bacteria
 2  4  4  9 -----------|-|   9    [S]     COG4950 Uncharacterized protein conserved in bacteria
 2  2  2  4 -----|-------|   4    [M]     COG4952 Predicted sugar isomerase
 2  4  6  8 -------|-----|  13    [U]     COG4964 Flp pilus assembly protein, secretin CpaC
 2  4  7 11 -----------|-|  15    [U]     COG4965 Flp pilus assembly protein TadB
 2  3  8 14 ----|--------|  41    [N    U]    COG4969 Tfp pilus assembly protein, major pilin PilA
 2  4  4  7 ------|-----|-  11    [R]     COG4980 Gas vesicle protein
 2  3  3  6 --|--------|--   7    [I]     COG4981 Enoyl reductase domain of yeast-type FAS1
 2  3  3  6 --|--------|--   7    [I]     COG4982 3-oxoacyl-[acyl-carrier protein] reductase
 2  2  3  3 --------|----|   3    [S]     COG4984 Predicted membrane protein
 2  3  7 16 ------------||  16    [C    O]    COG4987 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components
 2  4  6 14 ------------||  14    [R]     COG4989 Predicted oxidoreductase
 2  3  3  6 ------------||  12    [S]     COG4991 Uncharacterized protein with a bacterial SH3 domain homologue
 2  3  3  3 ------------||   3    [S]     COG4994 Uncharacterized protein conserved in bacteria
 2  3  3  3 ------|------|  17    [S]     COG4995 Uncharacterized protein conserved in bacteria
 2  2  3  3 ||------------   3    [L]     COG4998 Predicted endonuclease (RecB family)
 2  3  6 11 ----|--------|  11    [T]     COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation
 2  2  3  8 -------|----|-   8    [T]     COG5002 Signal transduction histidine kinase
 2  3  3  3 --||----------  17    [D    Z]    COG5019 Septin family protein
 2  3  3  3 --||----------  16    [G]     COG5020 Mannosyltransferase
 2  3  3  3 --||----------  14    [O]     COG5021 Ubiquitin-protein ligase
 2  3  3  3 --||----------  12    [Z]     COG5022 Myosin heavy chain
 2  3  3  3 --||----------  11    [Z]     COG5023 Tubulin
 2  3  3  3 --||----------  16    [D]     COG5024 Cyclin
 2  3  3  3 --||----------  10    [K]     COG5025 Transcription factor of the Forkhead/HNF3 family
 2  3  3  3 --||----------   7    [B]     COG5027 Histone acetyltransferase (MYST family)
 2  3  3  3 --||----------   7    [U]     COG5028 Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3
 2  3  3  3 --||----------   7    [O]     COG5029 Prenyltransferase, beta subunit
 2  3  3  3 --||----------   7    [U]     COG5030 Clathrin adaptor complex, small subunit
 2  3  3  3 --|---|-------   6    [H]     COG5031 Uncharacterized protein involved in ubiquinone biosynthesis
 2  3  3  3 --||----------  22    [T    D    B    L    U]    COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family
 2  3  3  3 --||----------   6    [K]     COG5033 Transcription initiation factor IIF, auxiliary subunit
 2  3  3  3 --||----------   6    [B]     COG5034 Chromatin remodeling protein, contains PhD zinc finger
 2  3  3  3 --||----------   6    [D    K    T]    COG5035 Cell cycle control protein
 2  3  3  3 --||----------   6    [P]     COG5036 SPX domain-containing protein involved in vacuolar polyphosphate accumulation
 2  3  3  3 --||----------   6    [T    G]    COG5037 Gluconate transport-inducing protein
 2  3  3  3 --||----------   7    [R]     COG5038 Ca2+-dependent lipid-binding protein, contains C2 domain
 2  3  3  3 --||----------   5    [T]     COG5040 14-3-3 family protein
 2  3  3  3 --||----------   5    [T    D    K]    COG5041 Casein kinase II, beta subunit
 2  3  4  4 --|----------|   5    [F]     COG5042 Purine nucleoside permease
 2  3  3  3 --||----------   5    [U]     COG5043 Vacuolar protein sorting-associated protein
 2  3  3  3 --||----------   6    [O]     COG5044 RAB proteins geranylgeranyltransferase component A (RAB escort protein)
 2  3  3  3 --||----------   5    [J]     COG5045 Ribosomal protein S10E
 2  3  3  3 --||----------   5    [O]     COG5046 Protein involved in Mod5 protein sorting
 2  3  3  3 --||----------   5    [U]     COG5047 Vesicle coat complex COPII, subunit SEC23
 2  3  3  3 --||----------  48    [R]     COG5048 FOG: Zn-finger
 2  3  3  3 --||----------   5    [L    D    A]    COG5049 5'-3' exonuclease
 2  3  3  3 --||----------   5    [J]     COG5051 Ribosomal protein L36E
 2  3  3  3 --||----------   5    [U]     COG5052 Protein involved in membrane traffic
 2  3  3  3 --||----------   5    [J]     COG5053 Translation initiation factor 4E (eIF-4E)
 2  3  3  3 --||----------   5    [O]     COG5054 Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins
 2  3  3  3 --||----------   5    [L]     COG5055 Recombination DNA repair protein (RAD52 pathway)
 2  3  3  3 --||----------   5    [I]     COG5056 Acyl-CoA cholesterol acyltransferase
 2  3  3  3 --||----------   5    [D    T]    COG5057 Phosphotyrosyl phosphatase activator
 2  3  3  3 --||----------   5    [U]     COG5058 Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, longevity assurance factor
 2  3  3  3 --||----------  22    [Z]     COG5059 Kinesin-like protein
 2  3  3  3 --||----------   4    [O    U]    COG5061 Oxidoreductin, endoplasmic reticulum membrane-associated protein involved in disulfide bond formation
 2  3  3  3 --||----------   4    [S]     COG5062 Uncharacterized membrane protein
 2  3  3  3 --||----------   4    [R]     COG5063 CCCH-type Zn-finger protein
 2  3  3  3 --||----------   4    [U]     COG5064 Karyopherin (importin) alpha
 2  3  3  3 --||----------   4    [P]     COG5065 Protein involved in inorganic phosphate transport
 2  3  3  3 --||----------   4    [U]     COG5066 VAMP-associated protein involved in inositol metabolism
 2  3  3  3 --||----------   4    [L    D]    COG5067 Protein kinase essential for the initiation of DNA replication
 2  3  3  3 --||----------   8    [K]     COG5068 Regulator of arginine metabolism and related MADS box-containing transcription factors
 2  3  3  3 --||----------   4    [Z]     COG5069 Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily)
 2  3  3  3 --||----------   5    [G    O    U]    COG5070 Nucleotide-sugar transporter
 2  3  3  3 --||----------   4    [O]     COG5071 26S proteasome regulatory complex component
 2  3  3  3 --||----------   4    [D]     COG5072 Serine/threonine kinase of the haspin family
 2  3  3  3 --||----------   5    [U]     COG5073 Vacuolar import and degradation protein
 2  3  3  3 --||----------   4    [U]     COG5074 t-SNARE complex subunit, syntaxin
 2  3  3  3 --||----------   4    [S]     COG5075 Uncharacterized conserved protein
 2  3  3  3 --||----------  21    [B    K]    COG5076 Transcription factor involved in chromatin remodeling, contains bromodomain
 2  3  3  3 --||----------   4    [O]     COG5077 Ubiquitin carboxyl-terminal hydrolase
 2  3  3  3 --||----------  36    [O]     COG5078 Ubiquitin-protein ligase
 2  3  3  3 --||----------   4    [U    D]    COG5079 Nuclear protein export factor
 2  3  3  3 --||----------   5    [U]     COG5080 Rab GTPase interacting factor, Golgi membrane protein
 2  3  3  3 --||----------   4    [S]     COG5081 Predicted membrane protein
 2  3  3  3 --||----------   9    [O    U]    COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger
 2  3  3  3 --||----------  10    [R]     COG5084 Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins
 2  3  3  3 --||----------   4    [S]     COG5085 Predicted membrane protein
 2  3  3  3 --||----------   3    [S]     COG5086 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [S]     COG5087 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [R]     COG5088 Rad5p-binding protein
 2  3  3  3 --||----------   3    [K]     COG5090 Transcription initiation factor IIF, small subunit (RAP30)
 2  3  3  3 --||----------   3    [R]     COG5091 Suppressor of G2 allele of skp1 and related proteins
 2  3  3  3 --||----------   3    [I]     COG5092 N-myristoyl transferase
 2  3  3  3 --||----------   3    [S]     COG5093 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [K]     COG5094 Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA)
 2  3  3  3 --||----------   3    [K]     COG5095 Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA)
 2  3  3  3 --||----------  10    [U]     COG5096 Vesicle coat complex, various subunits
 2  3  3  3 --||----------   3    [K]     COG5097 RNA polymerase II transcriptional regulation mediator
 2  3  3  3 --||----------   3    [B    D]    COG5098 Chromosome condensation complex Condensin, subunit D2
 2  3  3  3 --||----------  13    [J]     COG5099 RNA-binding protein of the Puf family, translational repressor
 2  3  3  3 --||----------   3    [U]     COG5100 Nuclear pore protein
 2  3  3  3 --||----------   6    [U]     COG5101 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily)
 2  3  3  3 --||----------   3    [U]     COG5102 Membrane protein involved in ER to Golgi transport
 2  3  3  3 --||----------   3    [D    K]    COG5103 Cell division control protein, negative regulator of transcription
 2  3  3  3 --||----------   3    [A]     COG5104 Splicing factor
 2  3  3  3 --||----------   3    [D]     COG5105 Mitotic inducer, protein phosphatase
 2  3  3  3 --||----------   3    [S]     COG5106 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [A]     COG5107 Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor
 2  3  3  3 --|----------|   3    [K]     COG5108 Mitochondrial DNA-directed RNA polymerase
 2  3  3  3 --||----------   3    [R]     COG5109 Uncharacterized conserved protein, contains RING Zn-finger
 2  3  3  3 --||----------   3    [O]     COG5110 26S proteasome regulatory complex component
 2  3  3  3 --||----------   3    [K]     COG5111 DNA-directed RNA polymerase III, subunit C34
 2  3  3  3 --||----------   3    [R]     COG5112 U1-like Zn-finger-containing protein
 2  3  3  3 --||----------   3    [O]     COG5113 Ubiquitin fusion degradation protein 2
 2  3  3  3 --||----------   3    [B]     COG5114 Histone acetyltransferase complex SAGA/ADA, subunit ADA2
 2  3  3  3 --||----------   3    [O]     COG5116 26S proteasome regulatory complex component
 2  3  3  3 --||----------   3    [J    U]    COG5117 Protein involved in the nuclear export of pre-ribosomes
 2  3  3  3 --||----------   3    [K]     COG5118 Transcription initiation factor TFIIIB, Bdp1 subunit
 2  3  3  3 --|---|-------   3    [R]     COG5119 Uncharacterized protein, contains ParB-like nuclease domain
 2  3  3  3 --||----------   3    [U]     COG5120 Membrane protein involved in Golgi transport
 2  3  3  3 --||----------   3    [U]     COG5122 Transport protein particle (TRAPP) complex subunit
 2  3  3  3 --||----------   3    [K]     COG5123 Transcription initiation factor IIA, gamma subunit
 2  3  3  3 --||----------   3    [D    R]    COG5124 Protein predicted to be involved in meiotic recombination
 2  3  3  3 --||----------   3    [S]     COG5125 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [C]     COG5127 Vacuolar H+-ATPase V1 sector, subunit C
 2  3  3  3 --||----------   3    [U]     COG5128 Transport protein particle (TRAPP) complex subunit
 2  3  3  3 --||----------   3    [R]     COG5129 Nuclear protein with HMG-like acidic region
 2  3  3  3 --||----------   3    [U    T]    COG5130 Prenylated rab acceptor 1 and related proteins
 2  3  3  3 --||----------   3    [K    D]    COG5132 Cell cycle control protein, G10 family
 2  3  3  3 --||----------   3    [S]     COG5133 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [S]     COG5134 Uncharacterized conserved protein
 2  3  3  3 --|---|-------   3    [S]     COG5135 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [A]     COG5136 U1 snRNP-specific protein C
 2  3  3  3 --||----------   3    [K    B]    COG5137 Histone chaperone involved in gene silencing
 2  3  3  3 --||----------   3    [S]     COG5138 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [S]     COG5139 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [O]     COG5140 Ubiquitin fusion-degradation protein
 2  3  3  3 --||----------   3    [R]     COG5141 PHD zinc finger-containing protein
 2  3  3  3 --||----------   3    [L]     COG5142 Oxidation resistance protein
 2  3  3  3 --||----------  10    [U]     COG5143 Synaptobrevin/VAMP-like protein
 2  3  3  3 --||----------   3    [K    L]    COG5144 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB2
 2  3  3  3 --||----------   3    [L]     COG5145 DNA excision repair protein
 2  3  3  3 --|---------|-   3    [H]     COG5146 Pantothenate kinase, acetyl-CoA regulated
 2  3  3  3 --||----------  10    [K    A    D]    COG5147 Myb superfamily proteins, including transcription factors and mRNA splicing factors
 2  3  3  3 --||----------   3    [O]     COG5148 26S proteasome regulatory complex, subunit RPN10/PSMD4
 2  3  3  3 --||----------   3    [K]     COG5149 Transcription initiation factor IIA, large chain
 2  3  3  3 --||----------   3    [K]     COG5150 Class 2 transcription repressor NC2, beta subunit (Dr1)
 2  3  3  3 --||----------   3    [K    L]    COG5151 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1
 2  3  3  3 --||----------   3    [R]     COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers
 2  3  3  3 --||----------   3    [U    I]    COG5153 Putative lipase essential for disintegration of autophagic bodies inside the vacuole
 2  3  3  3 --||----------   3    [J]     COG5154 RNA-binding protein required for 60S ribosomal subunit biogenesis
 2  3  3  3 --||----------   3    [D    O]    COG5155 Separase, a protease involved in sister chromatid separation
 2  3  3  3 --||----------   3    [D    O]    COG5156 Anaphase-promoting complex (APC), subunit 10
 2  3  3  3 --||----------   3    [K]     COG5157 RNA polymerase II assessory factor
 2  3  3  3 --||----------  11    [U]     COG5158 Proteins involved in synaptic transmission and general secretion, Sec1 family
 2  3  3  3 --||----------   3    [O]     COG5159 26S proteasome regulatory complex component
 2  3  3  3 --||----------   5    [O]     COG5160 Protease, Ulp1 family
 2  3  3  3 --||----------   3    [A]     COG5161 Pre-mRNA cleavage and polyadenylation specificity factor
 2  3  3  3 --||----------   3    [K]     COG5162 Transcription initiation factor TFIID, subunit TAF10 (also component of histone acetyltransferase SAGA)
 2  3  3  3 --||----------   3    [J]     COG5163 Protein required for biogenesis of the 60S ribosomal subunit
 2  3  3  3 --||----------   3    [K]     COG5164 Transcription elongation factor
 2  3  3  3 --||----------   3    [K    L    B]    COG5165 Nucleosome-binding factor SPN, POB3 subunit
 2  3  3  3 --||----------   3    [S]     COG5166 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [U]     COG5167 Protein involved in vacuole import and degradation
 2  3  3  3 --||----------  10    [K]     COG5169 Heat shock transcription factor
 2  3  3  3 --||----------   3    [T]     COG5170 Serine/threonine protein phosphatase 2A, regulatory subunit
 2  3  3  3 --||----------   3    [U]     COG5171 Ran GTPase-activating protein (Ran-binding protein)
 2  3  3  3 --||----------   3    [U]     COG5173 Exocyst complex subunit SEC6
 2  3  3  3 --||----------   3    [K]     COG5174 Transcription initiation factor IIE, beta subunit
 2  3  3  3 --||----------   3    [K]     COG5175 Transcriptional repressor
 2  3  3  3 --||----------   3    [A]     COG5176 Splicing factor (branch point binding protein)
 2  3  3  3 --||----------   3    [S]     COG5177 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [A]     COG5178 U5 snRNP spliceosome subunit
 2  3  3  3 --||----------   3    [K]     COG5179 Transcription initiation factor TFIID, subunit TAF1
 2  3  3  3 --||----------   3    [A]     COG5180 Protein interacting with poly(A)-binding protein
 2  3  3  3 --||----------   3    [A]     COG5181 U2 snRNP spliceosome subunit
 2  3  3  3 --||----------   3    [A]     COG5182 Splicing factor 3b, subunit 2
 2  3  3  3 --||----------   3    [A]     COG5183 Protein involved in mRNA turnover and stability
 2  3  3  3 --||----------   3    [D]     COG5185 Protein involved in chromosome segregation, interacts with SMC proteins
 2  3  3  3 --||----------   3    [A]     COG5186 Poly(A) polymerase
 2  3  3  3 --||----------   3    [O]     COG5187 26S proteasome regulatory complex component, contains PCI domain
 2  3  3  3 --||----------   3    [A]     COG5188 Splicing factor 3a, subunit 3
 2  3  3  3 --||----------   3    [K    D]    COG5189 Putative transcriptional repressor regulating G2/M transition
 2  3  3  3 --||----------  12    [K]     COG5190 TFIIF-interacting CTD phosphatases, including NLI-interacting factor
 2  3  3  3 --||----------   3    [R]     COG5191 Uncharacterized conserved protein, contains HAT (Half-A-TPR) repeat
 2  3  3  3 --||----------   3    [J]     COG5192 GTP-binding protein required for 40S ribosome biogenesis
 2  3  3  3 --||----------   6    [O    J]    COG5193 La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation
 2  3  3  3 --||----------   5    [O    D]    COG5194 Component of SCF ubiquitin ligase and anaphase-promoting complex
 2  3  3  3 --||----------   3    [S]     COG5195 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [U]     COG5196 ER lumen protein retaining receptor
 2  3  3  3 --||----------   3    [S]     COG5197 Predicted membrane protein
 2  3  3  3 --||----------   3    [R]     COG5198 Protein tyrosine phosphatase-like protein (contains Pro instead of catalytic Arg)
 2  3  3  3 --||----------   3    [Z]     COG5199 Calponin
 2  3  3  3 --||----------   3    [A]     COG5200 U1 snRNP component, mediates U1 snRNP association with cap-binding complex
 2  3  3  3 --||----------   3    [O]     COG5201 SCF ubiquitin ligase, SKP1 component
 2  3  3  3 --||----------   3    [S]     COG5202 Predicted membrane protein
 2  3  3  3 --||----------   3    [K]     COG5204 Transcription elongation factor SPT4
 2  3  3  3 --||----------   3    [O]     COG5206 Glycosylphosphatidylinositol transamidase (GPIT), subunit GPI8
 2  3  3  3 --||----------   3    [O]     COG5207 Isopeptidase T
 2  3  3  3 --||----------   3    [K]     COG5208 CCAAT-binding factor, subunit C
 2  3  3  3 --||----------   3    [R]     COG5209 Uncharacterized protein involved in cell differentiation/sexual development
 2  3  3  3 --||----------  25    [R]     COG5210 GTPase-activating protein
 2  3  3  3 --||----------   3    [K]     COG5211 RNA polymerase II-interacting protein involved in transcription start site selection
 2  3  3  3 --|----------|   3    [T]     COG5212 Low-affinity cAMP phosphodiesterase
 2  3  3  3 --||----------   3    [A]     COG5213 Polyadenylation factor I complex, subunit FIP1
 2  3  3  3 --||----------   3    [L]     COG5214 DNA polymerase alpha-primase complex, polymerase-associated subunit B
 2  3  3  3 --||----------   3    [U]     COG5215 Karyopherin (importin) beta
 2  3  3  3 --||----------   3    [S]     COG5216 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [D    Z]    COG5217 Microtubule-binding protein involved in cell cycle control
 2  3  3  3 --||----------   3    [B    D]    COG5218 Chromosome condensation complex Condensin, subunit G
 2  3  3  3 --||----------   3    [R]     COG5219 Uncharacterized conserved protein, contains RING Zn-finger
 2  3  3  3 --||----------   3    [D    K    L]    COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3
 2  3  3  3 --||----------   3    [K]     COG5221 Dopey and related predicted leucine zipper transcription factors
 2  3  3  3 --||----------   3    [R]     COG5222 Uncharacterized conserved protein, contains RING Zn-finger
 2  3  3  3 --||----------   3    [S]     COG5223 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [K]     COG5224 CCAAT-binding factor, subunit B
 2  3  3  3 --||----------   3    [J]     COG5225 Uncharacterized protein involved in ribosome biogenesis
 2  3  3  3 --||----------   3    [A]     COG5226 mRNA capping enzyme, guanylyltransferase (alpha) subunit
 2  3  3  3 --||----------   3    [O]     COG5227 Ubiquitin-like protein (sentrin)
 2  3  3  3 --||----------   3    [A]     COG5228 mRNA deadenylase subunit
 2  3  3  3 --||----------   3    [B    D]    COG5229 Chromosome condensation complex Condensin, subunit H
 2  3  3  3 --||----------   3    [S]     COG5230 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [C]     COG5231 Vacuolar H+-ATPase V1 sector, subunit H
 2  3  3  3 --||----------   3    [U]     COG5232 Preprotein translocase subunit Sec62
 2  3  3  3 --||----------   3    [U]     COG5233 Peripheral Golgi membrane protein
 2  3  3  3 --||----------   3    [O    Z]    COG5234 Beta-tubulin folding cofactor D
 2  3  3  3 --||----------   3    [L]     COG5235 Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit
 2  3  3  3 --||----------   3    [R]     COG5236 Uncharacterized conserved protein, contains RING Zn-finger
 2  3  3  3 --||----------   3    [S]     COG5237 Predicted membrane protein
 2  3  3  3 --||----------   3    [T    A]    COG5238 Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport
 2  3  3  3 --||----------   7    [A]     COG5239 mRNA deadenylase, exonuclease subunit and related nucleases
 2  3  3  3 --||----------   3    [U]     COG5240 Vesicle coat complex COPI, gamma subunit
 2  3  3  3 --||----------   3    [L]     COG5241 Nucleotide excision repair endonuclease NEF1, RAD10 subunit
 2  3  3  3 --||----------   3    [K    L]    COG5242 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4
 2  3  3  3 --||----------   3    [O]     COG5243 HRD ubiquitin ligase complex, ER membrane component
 2  3  3  3 --||----------   3    [D]     COG5244 Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B
 2  3  3  3 --||----------   3    [Z]     COG5245 Dynein, heavy chain
 2  3  3  3 --||----------   3    [A]     COG5246 Splicing factor 3a, subunit 2
 2  3  3  3 --||----------   3    [K]     COG5247 Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog)
 2  3  3  3 --||----------   3    [K]     COG5248 Transcription initiation factor TFIID, subunit TAF13
 2  3  3  3 --||----------   3    [U]     COG5249 Golgi protein involved in Golgi-to-ER retrieval
 2  3  3  3 --||----------   3    [K]     COG5250 RNA polymerase II, fourth largest subunit
 2  3  3  3 --||----------   3    [K]     COG5251 Transcription initiation factor TFIID, subunit TAF11
 2  3  3  3 --||----------   3    [R]     COG5252 Uncharacterized conserved protein, contains CCCH-type Zn-finger protein
 2  3  3  3 --||----------   5    [T]     COG5253 Phosphatidylinositol-4-phosphate 5-kinase
 2  3  3  3 --||----------   3    [S]     COG5254 Predicted membrane protein
 2  2  3  4 ------------||   4    [S]     COG5255 Uncharacterized protein conserved in bacteria
 2  4  5  5 ||------------   5    [R]     COG5258 GTPase
 2  3  3  3 --||----------   5    [B    K]    COG5259 RSC chromatin remodeling complex subunit RSC8
 2  3  3  3 --||----------   9    [L]     COG5260 DNA polymerase sigma
 2  3  3  3 --||----------   4    [D    T]    COG5261 Protein involved in regulation of cellular morphogenesis/cytokinesis
 2  3  3  3 --||----------   7    [B]     COG5262 Histone H2A
 2  3  3  3 --||----------   8    [O]     COG5264 Vacuolar transporter chaperone
 2  5  7 11 --|----------|  16    [O]     COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components
 2  3  3  3 --||----------   3    [J    O]    COG5269 Ribosome-associated chaperone zuotin
 2  5  5  6 ||------------   6    [J]     COG5270 PUA domain (predicted RNA-binding domain)
 2  3  3  3 --||----------   3    [R]     COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain
 2  3  3  3 --||----------  22    [O]     COG5272 Ubiquitin
 2  3  3  3 --||----------  17    [R]     COG5273 Uncharacterized protein containing DHHC-type Zn finger
 2  3  3  3 --||----------  12    [C    I]    COG5274 Cytochrome b involved in lipid metabolism
 2  3  3  3 --||----------   3    [R]     COG5275 BRCT domain type II
 2  3  3  3 --||----------  23    [Z]     COG5277 Actin and related proteins
 2  2  2  5 |----------|--   7    [S]     COG5282 Uncharacterized conserved protein
 2  3  5  7 ------------||   9    [S]     COG5283 Phage-related tail protein
 2  3  3  3 --||----------   3    [K]     COG5290 IkappaB kinase complex, IKAP component
 2  3  3  3 --||----------   3    [S]     COG5291 Predicted membrane protein
 2  3  3  3 --||----------   3    [K]     COG5296 Transcription factor involved in TATA site selection and in elongation by RNA polymerase II
 2  3  3  4 -----------|-|   4    [G]     COG5297 Cellobiohydrolase A (1,4-beta-cellobiosidase A)
 2  2  2  3 ------------||   3    [S]     COG5298 Uncharacterized protein conserved in bacteria
 2  3  3  7 -----------|-|   7    [R]     COG5302 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid
 2  2  3  3 ------|------|   4    [S]     COG5304 Uncharacterized protein conserved in bacteria
 2  4  4  5 |------------|   6    [S]     COG5306 Uncharacterized conserved protein
 2  3  3  3 --||----------   4    [U]     COG5308 Nuclear pore complex subunit
 2  3  3  3 --|----------|   6    [G]     COG5309 Exo-beta-1,3-glucanase
 2  2  2  5 |------------|   6    [Q]     COG5310 Homospermidine synthase
 2  2  3  4 |------------|   4    [S]     COG5323 Uncharacterized conserved protein
 2  3  3  3 --|-----|-----   3    [S]     COG5324 Uncharacterized conserved protein
 2  3  3  3 --||----------   6    [U]     COG5325 t-SNARE complex subunit, syntaxin
 2  3  3  3 --||----------  11    [T]     COG5329 Phosphoinositide polyphosphatase (Sac family)
 2  2  2  4 ------|------|   4    [S]     COG5331 Uncharacterized protein conserved in bacteria
 2  3  3  3 --||----------   9    [D    K    L]    COG5333 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit
 2  3  5 11 -------|-----|  14    [S]     COG5339 Uncharacterized protein conserved in bacteria
 2  3  3  5 |----------|--   7    [K]     COG5340 Predicted transcriptional regulator
 2  3  3  5 ------|------|   5    [S]     COG5346 Predicted membrane protein
 2  3  3  3 --||----------  14    [U]     COG5347 GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport
 2  2  2  5 ------------||   6    [R]     COG5350 Predicted protein tyrosine phosphatase
 2  3  3  3 --||----------   5    [R]     COG5354 Uncharacterized protein, contains Trp-Asp (WD) repeat
 2  3  3  3 --||----------   4    [R]     COG5366 Protein involved in propagation of M2 dsRNA satellite of L-A virus
 2  3  3  3 --||----------   3    [S]     COG5369 Uncharacterized conserved protein
 2  3  3  3 --||----------   5    [G    O]    COG5371 Golgi nucleoside diphosphatase
 2  3  3  3 --||----------   5    [S]     COG5374 Uncharacterized conserved protein
 2  2  2  4 ------------||   5    [L]     COG5377 Phage-related protein, predicted endonuclease
 2  3  3  3 ||------------   3    [R]     COG5378 Predicted nucleotide-binding protein
 2  2  2  3 ------|------|   3    [S]     COG5381 Uncharacterized protein conserved in bacteria
 2  3  3  9 -----------|-|  11    [S]     COG5383 Uncharacterized protein conserved in bacteria
 2  3  3  3 --||----------   3    [J]     COG5384 U3 small nucleolar ribonucleoprotein component
 2  3  4  6 --|----------|   6    [O]     COG5387 Chaperone required for the assembly of the mitochondrial F1-ATPase
 2  3  3  3 --||----------  13    [U    R]    COG5391 Phox homology (PX) domain protein
 2  2  2  5 |------------|   5    [S]     COG5402 Uncharacterized conserved protein
 2  2  2  3 -------|-----|   3    [S]     COG5403 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [K    L    B]    COG5406 Nucleosome binding factor SPN, SPT16 subunit
 2  3  3  3 --||----------   3    [U]     COG5407 Preprotein translocase subunit Sec63
 2  3  3  3 --||----------   8    [T]     COG5408 SPX domain-containing protein
 2  3  3  3 --||----------   6    [T]     COG5409 EXS domain-containing protein
 2  3  3  4 ------------||   6    [S]     COG5410 Uncharacterized protein conserved in bacteria
 2  3  3  3 --||----------   8    [T]     COG5411 Phosphatidylinositol 5-phosphate phosphatase
 2  3  3  4 ------|------|   4    [S]     COG5413 Uncharacterized integral membrane protein
 2  3  3  3 --||----------   3    [K]     COG5414 TATA-binding protein-associated factor
 2  3  3  3 --||----------   3    [R]     COG5415 Predicted integral membrane metal-binding protein
 2  2  2  3 ------|------|   4    [S]     COG5420 Uncharacterized conserved small protein containing a coiled-coil domain
 2  3  3  3 |-----|-------  24    [L]     COG5421 Transposase
 2  3  3  3 --||----------   5    [T]     COG5422 RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
 2  2  3  3 ||------------   3    [S]     COG5431 Uncharacterized metal-binding protein
 2  3  3  3 --||----------   3    [T]     COG5432 RING-finger-containing E3 ubiquitin ligase
 2  2  2  4 |------------|   4    [S]     COG5436 Predicted integral membrane protein
 2  2  3  5 ------------||   5    [S]     COG5437 Predicted secreted protein
 2  2  2  3 ------|------|   3    [S]     COG5439 Uncharacterized conserved protein
 2  3  4  4 ||------------   5    [S]     COG5440 Uncharacterized conserved protein
 2  2  3  5 -----------|-|  16    [K]     COG5450 Transcription regulator of the Arc/MetJ class
 2  3  3  4 --|----------|   4    [J]     COG5459 Predicted rRNA methylase
 2  3  4  4 ------------||   4    [S]     COG5460 Uncharacterized conserved protein
 2  4  4  8 ------|------|  52    [S]     COG5464 Uncharacterized conserved protein
 2  2  3  7 ---------|---|   7    [S]     COG5465 Uncharacterized conserved protein
 2  3  3  4 ------|------|   8    [S]     COG5469 Predicted metal-binding protein
 2  3  3  6 |------------|  11    [S]     COG5470 Uncharacterized conserved protein
 2  3  3  3 ------|------|   3    [S]     COG5474 Uncharacterized conserved protein
 2  4  4  6 --|----------|  12    [S]     COG5478 Predicted small integral membrane protein
 2  2  2  5 ------|------|   6    [S]     COG5480 Predicted integral membrane protein
 2  2  2  4 ------------||   4    [S]     COG5482 Uncharacterized conserved protein
 2  2  3  3 ||------------   3    [S]     COG5483 Uncharacterized conserved protein
 2  4  4  6 ------|------|   6    [R]     COG5485 Predicted ester cyclase
 2  3  4  4 -||-----------  12    [N]     COG5491 Conserved protein implicated in secretion
 2  3  3  7 ------------||  38    [N]     COG5492 Bacterial surface proteins containing Ig-like domains
 2  3  3  3 --|---------|-   5    [M]     COG5498 Predicted glycosyl hydrolase
 2  3  3  7 ------|------|   7    [K]     COG5499 Predicted transcription regulator containing HTH domain
 2  2  2  3 ------|------|   3    [S]     COG5500 Predicted integral membrane protein
 2  3  3  3 ----|--------|   3    [S]     COG5501 Predicted secreted protein
 2  2  2  4 -------|----|-   5    [O]     COG5504 Predicted Zn-dependent protease
 2  2  2  4 ------------||   4    [S]     COG5515 Uncharacterized conserved small protein
 2  3  4  6 -----------|-|   8    [Q]     COG5517 Small subunit of phenylpropionate dioxygenase
 2  3  3  4 ------------||   5    [R]     COG5518 Bacteriophage capsid portal protein
 2  4  4  4 ------------||   5    [M]     COG5520 O-Glycosyl hydrolase
 2  2  3  3 ------|------|   3    [S]     COG5526 Uncharacterized conserved protein
 2  3  3  4 ------------||   4    [L]     COG5527 Protein involved in initiation of plasmid replication
 2  3  3  3 |------------|   3    [R]     COG5529 Pyocin large subunit
 2  2  2  3 -------|-----|   3    [S]     COG5530 Predicted integral membrane protein
 2  3  3  3 --||----------   4    [O]     COG5533 Ubiquitin C-terminal hydrolase
 2  3  3  3 -------|-----|   4    [L]     COG5534 Plasmid replication initiator protein
 2  3  3  3 --||----------   5    [L]     COG5535 DNA repair protein RAD4
 2  3  3  3 --||----------   5    [O]     COG5536 Protein prenyltransferase, alpha subunit
 2  3  3  3 --||----------   4    [D]     COG5537 Cohesin
 2  3  3  3 --||----------   3    [U]     COG5538 Preprotein translocase subunit Sec66
 2  3  3  3 --||----------   5    [O]     COG5539 Predicted cysteine protease (OTU family)
 2  3  3  3 --||----------   4    [O]     COG5540 RING-finger-containing ubiquitin ligase
 2  3  3  3 --||----------   3    [O]     COG5541 Vesicle coat complex COPI, zeta subunit
 2  3  3  3 --||----------   3    [S]     COG5543 Uncharacterized conserved protein
 2  3  3  3 --|---|-------   3    [S]     COG5548 Small integral membrane protein
 2  2  3  3 -|----|-------  10    [O]     COG5550 Predicted aspartyl protease
 2  2  2  3 -----------|-|   3    [S]     COG5552 Uncharacterized conserved protein
 2  3  3  3 ------|------|   3    [R]     COG5553 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily
 2  2  2  3 ------|------|   3    [Q]     COG5554 Nitrogen fixation protein
 2  2  2  3 ------|------|   3    [N]     COG5555 Cytolysin, a secreted calcineurin-like phosphatase
 2  3  3  6 |------------|   7    [C]     COG5557 Polysulphide reductase
 2  3  3  3 ||------------   9    [L]     COG5558 Transposase
 2  3  3  3 |-----|-------   4    [S]     COG5559 Uncharacterized conserved small protein
 2  3  3  3 --||----------   4    [O]     COG5560 Ubiquitin C-terminal hydrolase
 2  3  3  3 --||----------   6    [O]     COG5574 RING-finger-containing E3 ubiquitin ligase
 2  3  3  3 --||----------   3    [L]     COG5575 Origin recognition complex, subunit 2
 2  3  3  3 --||----------  14    [K]     COG5576 Homeodomain-containing transcription factor
 2  2  2  4 -----------|-|   4    [S]     COG5579 Uncharacterized conserved protein
 2  3  3  3 --||----------   4    [O]     COG5580 Activator of HSP90 ATPase
 2  3  3  4 ------------||   5    [S]     COG5583 Uncharacterized small protein
 2  3  4  4 |-----------|-  14    [T]     COG5585 NAD+--asparagine ADP-ribosyltransferase
 2  2  2  5 -----------|-|   5    [S]     COG5586 Uncharacterized conserved protein
 2  3  4  5 --|----------|   5    [S]     COG5590 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [J]     COG5593 Nucleic-acid-binding protein possibly involved in ribosomal biogenesis
 2  3  3  3 --||----------   8    [S]     COG5594 Uncharacterized integral membrane protein
 2  3  3  3 --||----------   7    [O]     COG5596 Mitochondrial import inner membrane translocase, subunit TIM22
 2  3  3  3 --|----------|   5    [M]     COG5597 Alpha-N-acetylglucosamine transferase
 2  2  2  3 |------------|  13    [H]     COG5598 Trimethylamine:corrinoid methyltransferase
 2  3  3  3 --||----------   6    [T]     COG5599 Protein tyrosine phosphatase
 2  3  3  3 --||----------   5    [L]     COG5600 Transcription-associated recombination protein
 2  3  3  3 --||----------   3    [K]     COG5601 General negative regulator of transcription subunit
 2  3  3  3 --||----------   5    [B]     COG5602 Histone deacetylase complex, SIN3 component
 2  3  3  3 --||----------   3    [N]     COG5603 Subunit of TRAPP, an ER-Golgi tethering complex
 2  3  3  3 --||----------   4    [S]     COG5604 Uncharacterized conserved protein
 2  2  3  5 ------|------|   7    [S]     COG5606 Uncharacterized conserved small protein
 2  3  3  4 |------------|   6    [S]     COG5608 Conserved secreted protein
 2  2  2  4 ------|-----|-   7    [S]     COG5609 Uncharacterized conserved protein
 2  2  3  3 ----|--------|   3    [R]     COG5611 Predicted nucleic-acid-binding protein, contains PIN domain
 2  4  4  5 ------------||  13    [R]     COG5614 Bacteriophage head-tail adaptor
 2  3  3  3 |-----------|-   7    [S]     COG5617 Predicted integral membrane protein
 2  2  2  3 ------------||   5    [S]     COG5620 Uncharacterized conserved protein
 2  3  3  3 --||----------   3    [A]     COG5623 Pre-mRNA cleavage and polyadenylation factor IA/II complex, subunit CLP1
 2  3  3  3 --||----------   3    [K]     COG5624 Transcription initiation factor TFIID, subunit TAF12 (also component of histone acetyltransferase SAGA)
 2  3  4  5 ||------------   5    [K]     COG5625 Predicted transcription regulator containing HTH domain
 2  3  3  3 ------|------|   3    [S]     COG5626 Uncharacterized conserved small protein
 2  3  3  3 --||----------   3    [L]     COG5627 DNA repair protein MMS21
 2  2  3  3 ------------||   3    [R]     COG5628 Predicted acetyltransferase
 2  3  3  3 --||----------   3    [S]     COG5629 Predicted metal-binding protein
 2  3  3  3 --|----------|   3    [E]     COG5630 Acetylglutamate synthase
 2  3  3  3 --||----------   3    [S]     COG5636 Uncharacterized conserved protein, contains Zn-ribbon-like motif
 2  3  3  3 ------||------   5    [S]     COG5637 Predicted integral membrane protein
 2  3  3  3 --||----------   3    [S]     COG5638 Uncharacterized conserved protein
 2  3  3  3 --||----------  13    [K]     COG5641 GATA Zn-finger-containing transcription factor
 2  3  3  3 --||----------   3    [S]     COG5644 Uncharacterized conserved protein
 2  3  3  3 --||----------   6    [O]     COG5647 Cullin, a subunit of E3 ubiquitin ligase
 2  3  3  3 --||----------  10    [B]     COG5648 Chromatin-associated proteins containing the HMG domain
 2  3  3  7 |----------|--  10    [S]     COG5650 Predicted integral membrane protein
 2  3  3  5 -----------|-|   9    [S]     COG5654 Uncharacterized conserved protein
 2  3  3  3 --||----------   4    [O]     COG5656 Importin, protein involved in nuclear import
 2  3  3  3 --||----------   7    [D]     COG5657 CAS/CSE protein involved in chromosome segregation
 2  3  3  3 ------|------|  18    [L]     COG5659 FOG: Transposase
 2  2  2  5 ------|------|   5    [O]     COG5661 Predicted secreted Zn-dependent protease
 2  3  3  4 ------------||   4    [S]     COG5663 Uncharacterized conserved protein
 2  3  3  3 --||----------   4    [K]     COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit
 2  3  3  4 ||------------   4    [S]     COG5666 Uncharacterized conserved protein

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