Dennis Wright

  • E-Mail
  • Phone
    • (860) 486-9451
  • Fax
    • (860) 486-6857
  • Office
    • School of Pharmacy
      Room 629
  • Mail
    • University of Connecticut
      Dept. of Pharmaceutical Sciences
      69 North Eagleville Road
      Storrs, CT 06269-3092

Professor of Medicinal Chemistry

Wright Lab Website »

Educational Background

  • B.S. West Liberty State College, Chemistry
  • Ph.D. Ohio University, Chemistry
  • Postdoctoral Training: Stanford University, Chemistry

Research Interests

  • Development of small-molecule therapeutics based on complex natural products
  • Therapeutic development for infectious disease, cancer and neurodegenerative disorders

Selected Publications

  • VanHeyst, M.D., Oblak, E.Z., Wright, D.L. (2013) Stereodivergent Resolution of Oxabicyclic Ketones: Preparation of Key Intermediates for Platensimycin and Other Natural Products, J. Org. Chem. 78, 10555-9.
  • Ononye, S.N., VanHeyst, M.D., Oblak, E.Z., Ammar, M., Anderson, A.C., Wright, D.L. (2013) Tropolones as Lead-Like Natural Products: The Development of Potent Histone Deacetylase Inhibitors, ACS Med. Chem. Lett. 4, 757-61.
  • Cooper, H.D., Wright, D.L. (2013) The Tandem Ring Opening/Ring Closing Metathesis Route to Oxaspirocycles: An Approach to Phelligridin G, Molecules 18, 2438-2448.
  • Paulsen, J.L., Viswanathan, K., Wright, D.L., Anderson, A.C. (2013) Structural Analysis of the Active Sites of Dihydrofolate Reductase From Two Species of Candida Uncovers Ligand-induced Conformational Changes Shared Among Species, Bioorg. Med. Chem. Lett. 23, 1279-1284.
  • Viswanathan, K., Frey, K.M., Scocchera, E.W., Martin, B.D., Dwain, P.W., Alverson, J.B., Priestley, N.D., Anderson, A.C., Wright, D.L.  (2012) Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes,  PLoS ONE 7(2), e29434.
  • Oblak, E.Z., Wright, D.L.  (2011) Highly Substituted Oxabicyclic Derivatives from Furan: Synthesis of (±)-Platensimycin, Org. Lett. 13, 2263-5.