Robert K. Nakamoto
Primary AppointmentProfessor, Molecular Physiology and Biological Physics
- AB, Zoology, University of California, Berkeley, CA
- PhD, Biochemistry, University of Maryland, Baltimore, MD
- Postdoc, Biochemistry, Stanford University, Stanford, CA
- Postdoc, Biochemistry and Genetics, Yale University, New Haven, CT
Structure-Function of Active Transporters
Our goal is to understand the molecular mechanisms of these different transporters. We use a variety of biochemical, biophysical and structural approaches combined with genetic and molecular biological approaches to probe the structure-function relationships. In such ways, we can obtain measurements of the structural dynamics that occur during the transport cycle. The dynamics are correlated to the kinetics of the partial reactions occurring during transport and the energetics of these transitions. The data are used to generate models which can then be computationally simulated.